
Integrated Photoacoustic Ultrasound Real-Time Imaging For Brachytherapy TreatmentAward last edited on: 9/11/13
Sponsored Program
SBIRAwarding Agency
NIH : NCITotal Award Amount
$177,408Award Phase
1Solicitation Topic Code
-----Principal Investigator
Everette C BurdetteCompany Information
Phase I
Contract Number: 1R43CA180561-01Start Date: 8/12/13 Completed: 8/11/14
Phase I year
2013Phase I Amount
$177,408Public Health Relevance Statement:
Public Health Relevance:
Prostate cancer is diagnosed in approximately 240,000 men per year in the United States, making it the most common cancer afflicting men and second in the overall population. Brachytherapy (implantation of radioactive seeds into the prostate) is widely used in the treatment of prostate cancer, yet studies show that it is possible for men to receive suboptimal brachytherapy treatment, with doses either too high (leading to side effects and sometimes serious toxicity) or insufficient (leading to risk of cancer recurrence). A major contributor to these outcomes is the lack of existing techniques for physicians to visualize or quantify radiation dose within the prostate as seeds are implanted; the goal of the proposed research is to develop a system that achieves this capability in a manner that can be readily implemented in operating rooms on a widespread scale nationwide. Over 50,000 brachytherapy procedures are performed in the U.S. annually. Prevalence of the use of brachytherapy is in part due to its minimally invasive nature and relatively brief time commitment on the part of the patient when compared to external beam radiation or surgery. The success of prostate brachytherapy hinges on adequately dosing the prostate while avoiding excessive radiation to adjacent organs, most notably the urethra and rectum. Despite some improvements in technique, the basic methods of prostate brachytherapy have changed little over the past decade, and contemporary multi-center reports document considerable variability in brachytherapy practice with resultant toxicity and suboptimal outcomes. A recognized major contributor to these poor outcomes are source positioning errors and the onset of prostatic edema, which create regions of both inadequate dose as well as excessive dose. It is broadly recognized that there is a need for accurate image guidance, dynamic visualization of source positions, and intraoperative dose reconstruction as it evolves during the procedure. This work directly addresses these needs.
Project Terms:
absorption; Acoustics; Address; Adverse effects; Affect; Air; Anatomy; Animals; Area; base; Biological; Brachytherapy; Brachytherapy Seeds; Cancer Control; Cancer Etiology; cancer recurrence; Clinical; Computer software; computerized tools; Conventional Surgery; cost; Coupled; Deposition; design; Development; Diagnosis; Dose; dosimetry; Drug Delivery Systems; drug synthesis; Edema; Employee Strikes; Evaluation; experience; External Beam Radiation Therapy; Fiber; Fiber Optics; Future; Gel; Goals; Grant; Hearing; Image; image processing; Imagery; imaging modality; imaging probe; Implant; improved; in vivo; Integrated Delivery Systems; interstitial; Ionizing radiation; Lasers; Lead; Lightning (phenomenon); Location; Malignant neoplasm of prostate; Malignant Neoplasms; Maps; Measures; Mechanics; men; Metals; Methods; minimally invasive; Modification; molecular imaging; Monitor; Morbidity - disease rate; Mortality Vital Statistics; Nature; Needles; novel; Operating Rooms; operation; Operative Surgical Procedures; optical fiber; Optics; Organ; Outcome; Patients; Phase; photoacoustic imaging; Physicians; Physiologic pulse; Pilot Projects; Population; Positioning Attribute; Prevalence; Procedures; programs; Property; Prostate; Prostatic; public health relevance; Quantitative Evaluations; Radiation; Radioactive; Radioactive Seed Implantation; reconstruction; Rectum; Report (document); Reporting; Research; Risk; Robotics; Safety; Seed Implantation; Seeds; Signal Transduction; soft tissue; sound; Source; success; System; Systems Integration; Techniques; Testing; three-dimensional modeling; Time; Tissues; tool; Toxic effect; Transrectal Ultrasound; treatment planning; Tube; Ultrasonography; United States; uptake; Urethra; urinary; Validation; Work
Phase II
Contract Number: ----------Start Date: 00/00/00 Completed: 00/00/00