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Novel Cyclofructan Based Chiral Selectors For Pharmaceutical PurificationAward last edited on: 8/8/14
Sponsored Program
SBIRAwarding Agency
NIH : NIGMSTotal Award Amount
$1,120,715Award Phase
2Solicitation Topic Code
-----Principal Investigator
Yasith NanayakkaraCompany Information
AZYP LLC
700 Planetarium Place CRB Room 303
Arlington, TX 76019
Arlington, TX 76019
(817) 272-1399 |
questions@azypusa.com |
www.azypusa.com |
Location: Single
Congr. District: 06
County: Tarrant
Congr. District: 06
County: Tarrant
Phase I
Contract Number: 1R43RR032258-01Start Date: 4/15/11 Completed: 10/14/11
Phase I year
2011Phase I Amount
$139,867Public Health Relevance:
Pharmaceutical compounds that are chiral (from the Greek word for "hand") can exist as enantiomers (i.e., right and left-handed versions of the same basic compound). For medicines of this sort, usual one enantiomer (either the right or left-handed version) is the drug, while the other half causes side effects, different effects, similar effects or in limited cases, no effects. Since 1992 the Food and Drug Administration has had specific guidelines in place for the development and use of these types of drug products. In our proposed research we introduce a new class of chiral selectors called cyclofructans. We propose to develop synthetically altered cyclofructans that can be used to analyze, separate and purify most classes of chiral pharmaceutical compounds. Furthermore, these chiral selectors will prove useful in the enantiomeric separation of other biologically relevant chiral compounds (i.e. carcinogens). To show this is feasible, we will have to discover the optimal derivatized/bonded cyclofructans for the separation of a wide range of enantiomers. We believe the cyclofructans to be the most important class of chiral selector in at least the last 15 years. As a result of this proposed work, we will have better and less expensive pharmaceutical products that have fewer side effects and can be given in lower doses. Also we have better means to study stereo-selective effects of chiral biological toxins.
Thesaurus Terms:
Accounting;Adverse Effects;Amines;Area;Biological;Cancer Causing Agents;Carcinogens;Chromatography;Chromatography / Separation Science;Chromatography, High Performance Liquid;Chromatography, High Pressure Liquid;Chromatography, High Speed Liquid;Development;Development And Research;Dose;Drugs;Fda;Food And Drug Administration;Food And Drug Administration (U.S.);Generalized Growth;Greek;Growth;Guidelines;Hplc;Hand;High Pressure Liquid Chromatography;Isomerism;Lc/Ms;Left;Link;Liquid Substance;Marketing;Medication;Medicine;Modification;North America;Oligosaccharides;Oncogens;Optics;Organic Chemistry;Pharmaceutic Preparations;Pharmaceutical Agent;Pharmaceutical Preparations;Pharmaceuticals;Pharmacologic Substance;Pharmacological Substance;Phase;Play;Preparation;Process;Production;R &D;R&D;R01 Mechanism;R01 Program;Rpg;Research;Research Grants;Research Project Grants;Research Projects;Research Projects, R-Series;Resolution;Role;Sbir;Sbirs (R43/44);Sales;Science Of Medicine;Small Business Innovation Research;Small Business Innovation Research Grant;Sorting - Cell Movement;Technology;Testing;Tissue Growth;Toxin;Treatment Side Effects;Usfda;United States Food And Drug Administration;Work;Base;Commercialization;Drug /Agent;Drug/Agent;Enantiomer;Experiment;Experimental Research;Experimental Study;Fluid;High Performance Liquid Chromatography;Improved;Isomer;Liquid;Liquid Chromatography Mass Spectrometry;Molecular Recognition;Novel;Ontogeny;Research And Development;Research Study;Scale Up;Side Effect;Social Role;Sorting;Therapy Adverse Effect;Tool;Treatment Adverse Effect
Phase II
Contract Number: 9R44GM103359-02Start Date: 9/1/12 Completed: 8/31/14
Phase II year
2012(last award dollars: 2013)
Phase II Amount
$980,848Public Health Relevance:
NIH's mission to improve health outcomes for all people emphasizes the need to accelerate and strengthen clinical and translational research. Technology can play a vital role in achieving this goal through web-based tools for researchers that allow them to conduct, disseminate, and translate their research more efficiently and with higher quality. Currently, comprehensive web-based tools are rarely used in the service of clinical or translational research in the social and behavioral sciences. Social and behavioral research plays a critical role in advancing the understanding and prevention of public health problems, both at the individual level (e.g., drug and alcohol abuse) and at the systems level (e.g., health economics, delivery systems). The treatment and prevention of diabetes, obesity, drug abuse, violence, and myriad other public health concerns depend on good research that is conducted cost-effectively and translated efficiently. The proposed Research Implementation Management System (RIMS) will offer a suite of online research tools to streamline the various activities needed to conduct clinical and translational research in the social and behavioral sciences, including recruitment, retention, human participant protections, measure construction, data collection, and database management. This product will be developed and tested in response to the needs of clinical and translational researchers across a broad array of social and behavioral fields. The underlying web-based technology infrastructure of RIMS will be broadly applicable, providing customizable tools that can be easily integrated into a research protocol. RIMS will bridge geographic barriers by giving researchers with fewer institutional supports for research equal access to affordable, flexible technology. In effect, this SBIR will be able to support the research of scientists across multiple NIH Institutes, with particular relevanc for the National Institute for Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Institute on Aging (NIA), and the National Institute of Child Health and Human Development (NICHD). Bringing the RIMS product to market would broadly support NIH's mission to improve public health outcomes through strengthening capacity of clinical and translational science.
Public Health Relevance Statement:
NIH's mission to improve health outcomes for all people emphasizes the need to accelerate and strengthen clinical and translational research. Technology can play a vital role in achieving this goal through web-based tools for researchers that allow them to conduct, disseminate, and translate their research more efficiently and with higher quality. Currently, comprehensive web-based tools are rarely used in the service of clinical or translational research in the social and behavioral sciences. Social and behavioral research plays a critical role in advancing the understanding and prevention of public health problems, both at the individual level (e.g., drug and alcohol abuse) and at the systems level (e.g., health economics, delivery systems). The treatment and prevention of diabetes, obesity, drug abuse, violence, and myriad other public health concerns depend on good research that is conducted cost-effectively and translated efficiently. The proposed Research Implementation Management System (RIMS) will offer a suite of online research tools to streamline the various activities needed to conduct clinical and translational research in the social and behavioral sciences, including recruitment, retention, human participant protections, measure construction, data collection, and database management. This product will be developed and tested in response to the needs of clinical and translational researchers across a broad array of social and behavioral fields. The underlying web-based technology infrastructure of RIMS will be broadly applicable, providing customizable tools that can be easily integrated into a research protocol. RIMS will bridge geographic barriers by giving researchers with fewer institutional supports for research equal access to affordable, flexible technology. In effect, this SBIR will be able to support the research of scientists across multiple NIH Institutes, with particular relevanc for the National Institute for Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Institute on Aging (NIA), and the National Institute of Child Health and Human Development (NICHD). Bringing the RIMS product to market would broadly support NIH's mission to improve public health outcomes through strengthening capacity of clinical and translational science.
Project Terms:
Address; Alcohol abuse; Area; base; Behavioral; Behavioral Research; behavioral/social science; Child; Child health care; Clinical; Clinical Data; clinical practice; Clinical Research; Clinical Sciences; Collaborations; commercial application; commercialization; Computer software; cost; cost effective; cost effectiveness; Data Base Management; Data Collection; data management; Data Quality; Data Security; design; Development; Diabetes prevention; Drug abuse; effectiveness research; Ensure; Evaluation; experience; Feedback; flexibility; Foundations; Goals; Health; health economics; Health Insurance Portability and Accountability Act; Healthcare; Human; Human Development; implementation research; improved; Individual; innovation; Institutes; Institutional Review Boards; Internet; Letters; Marketing; Measurement; Measures; meetings; Methodology; Methods; Mission; Modification; National Institute of Drug Abuse; National Institute of Mental Health (U.S.); National Institute on Aging; Obesity; Online Systems; Outcome; Participant; Patient Care; Peer Review; Phase; Play; Prevention; Preventive; Principal Investigator; product development; programs; Protocols documentation; public health medicine (field); Publications; Randomized; Recording of previous events; Recruitment Activity; Reporting; Research; Research Activity; research and development; Research Infrastructure; Research Personnel; Research Support; response; Role; satisfaction; Scientific Advances and Accomplishments; Scientist; Services; Small Business Innovation Research Grant; social; success; symposium; System; Technology; Test Result; Testing; Time; tool; Translating; Translational Research; Translations; United States National Institutes of Health; usability; Violence; Work