The objective of this Phase I SBIR proposal is to provide improved therapies for the treatment of periodontal disease. Periodontal Disease is a chronic infectious disease of the oral cavity that effects about 35 % of the adult population in the United States, or slightly more than 40 million people.1-12 In severe cases, periodontal disease can lead to a failure of the underlying bone structure and necessitate surgical extraction and replacement of the teeth. In the U.S alone, the cost of treating periodontal disease was estimated at $19 billion dollars annually in 19984. The innovation proposed is to produce multifunctional, surface-modified nanoparticle carriers that are designed to bind robustly to hard tissue surfaces and bacterial biofilms, and may deliver multiple therapeutic payloads. Because the nanoparticles may bind to tissue surfaces and to bacterial biofilms, the carriers may have substantive (long lasting) therapeutic effects within the periodontal pocket, a major shortcoming of current therapies. The ability to localize and chemically attach the drug-carrier within the periodontium is a major advantage of the proposed innovation, since conventional therapies all suffer from the fact that the drugs are rapidly cleared by the turnover of gingival crevicular fluid (saliva).7 The proposed innovation, if successful, will be capable of managing multiple therapeutic chemistries and deliver them to the periodontal pocket and gingival tissues at efficacious levels over an extended period of time, without repeated intervention from a clinician.
Public Health Relevance: Periodontal Disease is a chronic infectious disease of the oral cavity that effects about 35 % of the adult population in the United States, or slightly more than 40 million people. This SBIR seeks to overcome the shortcomings of current therapies for periodontal disease, and to provide a therapy that is capable of managing multiple therapeutic chemistries, delivering them to disease sites over an extended period of time, without the repeated intervention from a clinician.
Thesaurus Terms: 21+ Years Old;Adult;Adverse Effects;Anti-Bacterial Agents;Antibacterial Agents;Bacterial Infections;Binding;Binding (Molecular Function);Bisphosphonates;Body Tissues;Bone;Bone And Bones;Bones And Bone Tissue;Buccal Cavity;Cavitas Oris;Cementum;Chemistry;Chronic;Communicable Diseases;Cristobalite;Data;Dental;Dental Care;Dental Cementum;Dental Enamel;Dental Procedure;Dentin;Development;Dimensions;Disease By Site;Disorder By Site;Douching, Other Than Vaginal;Drug Carriers;Drugs;Enamel;Flr;Failure (Biologic Function);Funding;Gingiva;Gingival;Gingival Crevicular Fluid;Gingival Exudate;Head And Neck, Buccal Cavity;Head And Neck, Saliva;Human, Adult;In Vitro;Industry;Infection;Infectious Disease Pathway;Infectious Diseases;Infectious Diseases And Manifestations;Infectious Disorder;Intervention;Intervention Strategies;Irrigation;Irrigation, Other Than Vaginal;Laboratories;Lavage;Lead;Medication;Microbial Biofilms;Modality;Molecular Interaction;Mouth;Nonvaginal Irrigation;Nonvaginal Lavage;Operation;Operative Procedures;Operative Surgical Procedures;Oral Cavity;Paradentium;Paradentiums;Parodontosis;Patients;Pb Element;Penetration;Periodontal Diseases;Periodontal Pocket;Periodontium;Pharmaceutic Preparations;Pharmaceutical Preparations;Phase;Population;Sbir;Sbirs (R43/44);Safety;Saline;Saline Solution;Saliva;Sand;Science Of Chemistry;Silica;Silicon Dioxide;Small Business Innovation Research;Small Business Innovation Research Grant;Structure;Surface;Surgical;Surgical Interventions;Surgical Procedure;Technology;Therapeutic;Therapeutic Agents;Therapeutic Effect;Time;Tissues;Tooth;Tooth Supporting Structures;Tooth Tissue;Tooth Structure;Treatment Side Effects;Tridymite;United States;Adult Human (21+);Anti-Bacterial;Anti-Microbial;Antibacterial;Antimicrobial;Aqueous;Bacterial Disease;Base;Biocompatibility;Biofilm;Biomaterial Compatibility;Biphosphonate;Bisphosphonate;Bone;Conventional Therapy;Cost;Design;Designing;Diphosphonate;Drug /Agent;Drug/Agent;Failure;Functional Group;Heavy Metal Pb;Heavy Metal Lead;Improved;Innovate;Innovation;Innovative;Interventional Strategy;Irrigation Therapy;Lavage Therapy;Nano Particle;Nano Sized;Nanoparticle;Nanosized;Oral Bacteria;Oral Flora;Periodontal Disorder;Periodontium Disease;Periodontium Disorder;Prevent;Preventing;Prototype;Restorative Composite;Side Effect;Surgery;Teeth;Therapy Adverse Effect;Tooth Enamel;Treatment Adverse Effect;Water Solution
