Vitamin D plays a critical role in calcium metabolism and bone health in children and adults. It is now recognized that every tissue and cell in the body have a vitamin D receptor and thus every tissue and cell in the body is a target for vitamin D action. Studies suggest that increased exposure to sunlight and increased vitamin D intake reduces risk of many chronic diseases including autoimmune diseases, heart disease, infectious diseases, type II diabetes and cancer. Vitamin D deficiency and insufficiency is the most common nutritional deficiency and medical condition in children and adults throughout the United States. The major source of vitamin D for children and adults is exposure to sunlight. There is little vitamin D in the diet and thus to maintain a normal healthy vitamin D status requires taking a vitamin D supplement. Patients with malabsorption and children and adults who are infirm and unable to be exposed to any sunlight are at particularly high risk for vitamin D deficiency and its health consequences. Artificial ultraviolet irradiation is also a good source of vitamin D. KBD Inc. is a small business that makes the Sperti vitamin D producing lamp that has been in existence for more than 50 years and marketed for producing vitamin D. The lamp has been modified so that most of the spectral output is in the UVB region thus maximally producing vitamin D. The goal of this grant is to take this newly designed lamp and test its effectiveness in producing vitamin D in patients with inflammatory bowel disease who have been demonstrated to malabsorb vitamin D. Adult IBD patients with skin types 2,3,4 and 5 will be exposed to suberythemal dose of UVB radiation from the Sperti fluorescent lamp three times a week for three months. Blood levels of 25-hydroxyvitamin D, a measure of vitamin D status, will be the primary outcome for the study. Results from this study should provide efficacy data to support the commercial development of this novel vitamin D producing fluorescent lamp not only for patients with malabsorption syndromes but also elderly in nursing homes and for children and adults who cannot be exposed to sunlight and have a difficult time taking a vitamin D supplement. , ,
Public Health Relevance: The goal of this grant is to obtain data that exposure to a novel Sperti fluorescent vitamin D producing lamp is effective in improving the vitamin D status of patients with inflammatory bowel disease who have documented vitamin D malabsorption. It is anticipated that results from this grant will provide the impetus for the small business KBD Inc. to market and sell its product to patients who suffer from the intestinal malabsorption syndromes and who are vitamin D deficient.
Thesaurus Terms: (3 Beta,5z,7e)-9,10-Secocholesta-5,7,10(19)-Trien-3-Ol;0-11 Years Old;1,25-Dihydroxycholecalciferol Receptors;1,25-Dihydroxyvitamin D3 Receptors;21+ Years Old;25-Hydroxycholecalciferol;25-Hydroxyvitamin D 3;25-Hydroxyvitamin D3;25-Hydroxy-D3;25-Hydroxyvitamin D;7,8-Didehydrocholesterol;7-Dhc;7-Dehydrocholesterol;9,10-Secocholesta-5,7,10(19)-Trien-3-Ol, (3beta,5z,7e)-;9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol, (3beta,5z,7e)-;Adult;Aged 65 And Over;American;Autoimmune Diseases;Blood;Body Tissues;Bread;Businesses;Calcidiol;Calcifediol;Calciol;Calibration;Cancers;Cardiac Diseases;Cardiac Disorders;Cells;Cereals;Child;Child Youth;Children (0-21);Cholecalciferol;Cholecalciferol Receptors;Chronic Disease;Chronic Illness;Clinical Trials;Clinical Trials, Unspecified;Communicable Diseases;Crohn's Disease;Crohn's Disorder;Dairy Products;Data;Development;Devices;Diabetes Mellitus, Adult-Onset;Diabetes Mellitus, Ketosis-Resistant;Diabetes Mellitus, Non-Insulin-Dependent;Diabetes Mellitus, Noninsulin Dependent;Diabetes Mellitus, Slow-Onset;Diabetes Mellitus, Stable;Diabetes Mellitus, Type 2;Diabetes Mellitus, Type Ii;Diet;Dose;Effectiveness;Elderly;Elderly, Over 65;Enteritis, Granulomatous;Epidemiology;Exposure To;Fats;Fatty Acid Glycerol Esters;Food;Fracture;Gastroenterologist;Goals;Grain;Grant;Health;Heart Diseases;Hip Fractures;Housing;Human;Human, Adult;Human, Child;Human, General;In Vitro;Infectious Disease Pathway;Infectious Diseases;Infectious Diseases And Manifestations;Infectious Disorder;Inflammatory Bowel Diseases;Inflammatory Bowel Disorder;Inflammatory Intestinal Disease;Inflammatory Intestinal Disorder;Intake;Laboratories;Laboratory Study;Lactose Intolerance;Lactose Malabsorption;Lipodystrophy, Intestinal;Mody;Malabsorption Syndromes;Malignant Neoplasms;Malignant Tumor;Malnutrition;Man (Taxonomy);Man, Modern;Marketing;Maturity-Onset Diabetes Mellitus;Measures;Medical;Milk;Modeling;Niddm;Non-Insulin Dependent Diabetes;Non-Insulin-Dependent Diabetes Mellitus;Nursing Homes;Nutritional Deficiency;Outcome Study;Output;Pth (1-84);Pth Protein, Human;Parathyroid Hormone;Parathyroid Hormone (1-84);Parathyroid Hormones;Patients;Play;Production;Receptors, 1,25-Dihydroxyvitamin D 3;Receptors, Calcitriol;Reticuloendothelial System, Blood;Risk;Role;Skin;Source;Standardization;Study Subject;Sun Exposure;Sunlight;Syndrome;T2d;T2dm;Testing;The Sun;Time;Tissues;Type 2 Diabetes;Type Ii Diabetes;Uv Irradiated;Uv Irradiation;Uv Irridated;Uvb;Uvb Radiation;Ulcerated Colitis;Ulcerative Colitis;Ultraviolet B Radiation;Undernutrition;United States;Vdr;Vit D;Vitamin D;Vitamin D 3;Vitamin D 3 Receptors;Vitamin D Deficiency;Vitamin D Receptors;Vitamin D3;Vitamin D3 Receptor;Whipple Disease;Work;Adult Human (21+);Adult Onset Diabetes;Advanced Age;Autoimmune Disorder;Bone Fracture;Bone Health;Calcium Metabolism;Children;Cholesta-5,7-Dien-3 Beta-Ol;Chronic Disease/Disorder;Chronic Disorder;Clinical Investigation;Cost Effective;Design;Designing;Dietary Deficiency;Elders;Eleocolitis;Gastrointestinal Absorption Disorder;Geriatric;Granulomatous Enterocolitis;Hpth(1-84);Heart Disorder;High Risk;Human Pth Protein;Improved;Intestinal Malabsorption;Ketosis Resistant Diabetes;Late Life;Later Life;Malabsorption;Malignancy;Maturity Onset Diabetes;Mid Life;Mid-Life;Middle Age;Middle Aged;Midlife;Neoplasm/Cancer;Novel;Nursing Home;Older Adult;Older Person;Parathormone;Parathyroid Hormone, Human;Prevent;Preventing;Primary Outcome;Provitamin D(3);Public Health Relevance;Regional Enteritis;Senior Citizen;Skeletal;Social Role;Solar Exposure;Sun Protection;Ultra Violet Irradiation;Ultraviolet Irradiation;Youngster
