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Reducing Methadone's Arrhythmic PotentialAward last edited on: 7/15/10
Sponsored Program
SBIRAwarding Agency
NIH : NHLBITotal Award Amount
$102,910Award Phase
1Solicitation Topic Code
-----Principal Investigator
John C SombergCompany Information
Academic Pharmaceuticals Inc
21 Skokie Valley Road Suite G3
Lake Bluff, IL 60044
Lake Bluff, IL 60044
(847) 735-1170 |
N/A |
N/A |
Location: Single
Congr. District: 10
County: Lake
Congr. District: 10
County: Lake
Phase I
Contract Number: 1R43HL095160-01A1Start Date: 4/15/10 Completed: 10/31/10
Phase I year
2010Phase I Amount
$102,910Public Health Relevance:
Methadone is frequently used for pain treatment and drug addiction, but the current formulation poses a serious risk of arrhythmias. The R isomer of methadone does not cause the same electrophysiologic changes (QT prolongation) and thus would not pose the same risk for arrhythmias. Studies in this grant set out to show that the R isomer is a safer methadone and would pose less of a risk for life threatening arrhythmias to patient.
Thesaurus Terms:
3-Heptanone, 6-(Dimethylamino)-4,4-Diphenyl-; Absence Of Pain Sensation; Absence Of Sensibility To Pain; Adanon; Addiction, Drug; Althose; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Animals; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Arrhythmia; Boxing; Canine Species; Canis Familiaris; Cardiac Arrhythmia; Cardiac Diseases; Cardiac Disorders; Cardiovascular; Cardiovascular Body System; Cardiovascular System; Cardiovascular System (All Sites); Chemical Dependence; Communities; Dependence, Drug; Dogs; Dolophine; Dose; Drug Addiction; Drug Dependency; Drug Formulations; Drugs; Ecg; Ekg; Electrocardiogram; Electrocardiography; Evaluation; Feels No Pain; Formulation; Formulations, Drug; Grant; Heart Arrhythmias; Heart Diseases; Isomerism; K Element; Label; Laboratories; Life; Maintenance Therapy; Mammals, Dogs; Medication; Methadone; Methadose; Modeling; No Sensitivity To Pain; Organ System, Cardiovascular; Pain; Painful; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Potassium; Reporting; Risk; Safety; Stereoisomer; Sudden Death; Surface; Therapeutic; Time; Torsades De Pointes; Vascular, Heart; Ventricular Tachycardia; Woman; Addiction; Analgesia; Base; Canine; Circulatory System; Domestic Dog; Drug/Agent; Heart Disorder; Isomer; Man; Man's; Milligram; Public Health Relevance
Phase II
Contract Number: ----------Start Date: 00/00/00 Completed: 00/00/00