
Generating Blood-Based Diagnosis For Alzheimer DiseaseAward last edited on: 10/9/12
Sponsored Program
SBIRAwarding Agency
NIH : NIATotal Award Amount
$1,767,258Award Phase
2Solicitation Topic Code
-----Principal Investigator
Eugenia WangCompany Information
Advanced Genomic Technology LLC (AKA: AGT)
51 US Highway 42 Unit 433
Louisville, KY 40241
Louisville, KY 40241
Location: Single
Congr. District: 03
County: Jefferson
Congr. District: 03
County: Jefferson
Phase I
Contract Number: 1R44AG035410-01Start Date: 4/15/10 Completed: 9/30/10
Phase I year
2010Phase I Amount
$107,000Public Health Relevance:
At present, the absence of any blood-based diagnosis for Alzheimer"s disease (AD) requires patients to enduring arduous neuropsychological testing, invasive cerebrospinal fluid tapping, and/or expensive MRI or PET imaging, with definitive diagnosis deferred until brain autopsy. Our preliminary findings, based on new science concerning a novel molecular species, microRNAs (miR) and their "see-saw" partial repression of the expression of their target gene(s), suggest that potential disease biomarkers for AD are detectable systemical- ly in peripheral blood mononuclear cells and/or serum/plasma, and may be quantified as miR-Target Pair Ra- tios (TPR). Our plan is to define AD-specific TPR indices, initially focusing on miR-34a and its target, SIRT1, whose reduction is known to be associated with increased Tau and A242, two hallmarks of AD etiopathogene- sis; our ultimate goal is a "Tool-Box" of TPR indices, miR-34a/SIRT1-TPR being the first such AD diagnostic, indicating not only disease presence, but also its progress (and even drug efficacy monitoring), a huge strate- gic gain for the victims of this costly disease, and our society at large!
Thesaurus Terms:
3' Untranslated Regions; 3'utr; 3,4',5-Stilbenetriol; 3,5,4'-Trihydroxystilbene; App Processing; Address; Age; Aged 65 And Over; Aging; Alzheimer; Alzheimer Disease; Alzheimer Sclerosis; Alzheimer Syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers Disease; Amyloid Plaques; Apoptosis; Apoptosis Pathway; Assay; Autopsy; Back; Binding; Binding (Molecular Function); Bioassay; Biogenesis; Biologic Assays; Biological Assay; Blood; Blood Plasma; Blood Serum; Boxing; Brain; Brain Pathology; Ccne2 Protein; Cdk4; Cdk4 Gene; Cmm3; Caloric Restriction; Care Givers; Care, Health; Caregivers; Cell Communication And Signaling; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Cell Signaling; Cells; Cerebrospinal Fluid; Code; Coding System; Cohort Studies; Concurrent Studies; Dna; Dna Damage Repair; Dna Repair; Deacetylase; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deoxyribonucleic Acid; Diagnosis; Diagnostic; Disease; Disorder; Dorsum; Down-Regulation; Down-Regulation (Physiology); Downregulation; Elderly; Elderly, Over 65; Encephalon; Encephalons; Equilibrium; Evaluation; Exhibits; Expression Profiling; Expression Signature; Family; Feasibility Studies; Foot; G1/S-Specific Cyclin E2; Gene Expression; Gene Expression Profile; Gene Products, Rna; Gene Targeting; Gene Transcription; Genes; Genes, P53; Genetic Transcription; Goals; Healthcare; Individual; Intracellular Communication And Signaling; Investigation; Investments; Knowledge; Lead; Length Of Life; Link; Longevity; Mgc14458; Mr Imaging; Mr Tomography; Mri; Mt-Bound Tau; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Micro Rna; Micrornas; Modeling; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Monitor; Mononuclear; Nmr Imaging; Nmr Tomography; Nervous System, Brain; Neuritic Plaques; Neurofibrillary Tangles; Neuropsychologic Tests; Neuropsychological Tests; Nuclear Magnetic Resonance Imaging; Origin Of Life; Oxidation-Reduction; Oxidative Stress; P53; Pbmc; Pet; Pet Scan; Pet Imaging; Petscan; Pett; Psk-J3; Participant; Patients; Pb Element; Peripheral; Peripheral Blood Mononuclear Cell; Pes; Phase; Physiologic; Physiological; Pilot Projects; Plasma; Positron Emission Tomography Scan; Positron-Emission Tomography; Primary Senile Degenerative Dementia; Printing; Production; Protein Family; Proteins; Proton Magnetic Resonance Spectroscopic Imaging; Psychologic Tests; Psychological Tests; Rna; Rna Expression; Rna, Non-Polyadenylated; Rna, Noncoding; Rna, Nontranslated; Rna, Untranslated; Rad.-Pet; Redox; Repression; Research; Research Specimen; Resveratrol; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Ribonucleic Acid; Risk; Sampling; Science; Screening Procedure; Senescence; Senile Plaques; Serum; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Specimen; Stress; Synapses; Synaptic; Tp53; Tp53 Gene; Trp53; Targetings, Gene; Testing; Transcription; Transcription, Genetic; Translations; Tumor Protein P53 Gene; Unscheduled Dna Synthesis; Untranslated Rna; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; Zeugmatography; Abnormally Aggregated Tau Protein; Advanced Age; Aggregation Of Microtubule Associated Protein Tau; Aggregation Of Microtubule-Associated Protein Tau; Amyloid Beta Plaque; Amyloid Precursor Protein Processing; Amyloid-B Plaque; Balance; Balance Function; Base; Biological Signal Transduction; Biomarker; Calorie Restriction; Cohort; Cored Plaque; Cyclin E2; Dementia Of The Alzheimer Type; Diffuse Plaque; Disease/Disorder; Drug Efficacy; Elders; Feeding; Filamentous Tau Inclusion; Foot; Gene Expression Signature; Gene Product; Geriatric; Heavy Metal Pb; Heavy Metal Lead; Indexing; Injury Response; Interest; Late Life; Later Life; Life Span; Lifespan; Meetings; Member; Mirna; Microtubule Associated Protein Tau; Microtubule Associated Protein Tau Aggregation; Microtubule Associated Protein Tau Deposit; Microtubule Bound Tau; Microtubule-Associated Protein Tau; Microtubule-Associated Protein Tau Aggregation; Microtubule-Associated Protein Tau Deposit; Microtubule-Bound Tau; Molecuar Profile; Molecular Signature; Necropsy; Neurofibrillary Degeneration; Neurofibrillary Lesion; Neurofibrillary Pathology; New Diagnostics; Next Generation Diagnostics; Novel; Novel Diagnostics; Older Adult; Older Person; Oxidation Reduction Reaction; Paired Helical Filament Of Tau; Pilot Study; Polyphenol; Postmortem; Primary Degenerative Dementia; Protein Expression; Public Health Relevance; Red Wine; Repository; Response To Injury; Screening; Screenings; Self-Aggregate Tau; Senescence; Senescent; Senile Dementia Of The Alzheimer Type; Senior Citizen; Spinal Fluid; Success; Tangle; Tau; Tau Phf; Tau Phf Formation; Tau Proteins; Tau Accumulation; Tau Aggregate; Tau Aggregation; Tau Factor; Tau Fibrillization; Tau Filament; Tau Filament Assembly; Tau Neurofibrillary Tangle; Tau Oligomer; Tau Paired Helical Filament; Tau Paired Helical Filament Formation; Tau Polymerization; Tau Self-Aggregate; Tau-Tau Interaction; Tool; Transcriptome; Trend
Phase II
Contract Number: 4R44AG035410-02Start Date: 4/15/10 Completed: 11/30/12
Phase II year
2011(last award dollars: 2012)
Phase II Amount
$1,660,258Public Health Relevance:
At present, the absence of any blood-based diagnosis for Alzheimer""s disease (AD) requires patients to enduring arduous neuropsychological testing, invasive cerebrospinal fluid tapping, and/or expensive MRI or PET imaging, with definitive diagnosis deferred until brain autopsy. Our preliminary findings, based on new science concerning a novel molecular species, microRNAs (miR) and their ""see-saw"" partial repression of the expression of their target gene(s), suggest that potential disease biomarkers for AD are detectable systemical- ly in peripheral blood mononuclear cells and/or serum/plasma, and may be quantified as miR-Target Pair Ra- tios (TPR). Our plan is to define AD-specific TPR indices, initially focusing on miR-34a and its target, SIRT1, whose reduction is known to be associated with increased Tau and A242, two hallmarks of AD etiopathogene- sis;our ultimate goal is a ""Tool-Box"" of TPR indices, miR-34a/SIRT1-TPR being the first such AD diagnostic, indicating not only disease presence, but also its progress (and even drug efficacy monitoring), a huge strate- gic gain for the victims of this costly disease, and our society at large!
Thesaurus Terms:
3'untranslated Regions;3'utr;3,4',5-Stilbenetriol;3,5,4'-Trihydroxystilbene;App Processing;Address;Age;Aged 65 And Over;Aging;Alzheimer;Alzheimer Type Dementia;Alzheimer Disease;Alzheimer Sclerosis;Alzheimer Syndrome;Alzheimer's;Alzheimer's Disease;Alzheimers Dementia;Alzheimers Disease;Amyloid Plaques;Apoptosis;Apoptosis Pathway;Assay;Autopsy;Autoregulation;Back;Binding;Binding (Molecular Function);Bioassay;Biogenesis;Biologic Assays;Biological Assay;Blood;Blood Plasma;Blood Reticuloendothelial System;Blood Serum;Boxing;Brain;Brain Nervous System;Brain Pathology;Ccne2 Protein;Cdk4;Cdk4 Gene;Cmm3;Caloric Restriction;Care Givers;Caregivers;Cell Communication And Signaling;Cell Cycle;Cell Division Cycle;Cell Signaling;Cells;Cerebrospinal Fluid;Code;Coding System;Cohort Studies;Concurrent Studies;Dna;Dna Damage Repair;Dna Repair;Deacetylase;Deoxyribonucleic Acid;Diagnosis;Diagnostic;Disease;Disorder;Dorsum;Down-Regulation;Down-Regulation (Physiology);Downregulation;Elderly;Encephalon;Equilibrium;Evaluation;Exhibits;Expression Profiling;Expression Signature;Family;Feasibility Studies;G1/S-Specific Cyclin E2;Gene Action Regulation;Gene Down-Regulation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Regulation;Gene Regulation Process;Gene Targeting;Gene Transcription;Genes;Genetic Transcription;Genotoxic Stress;Goals;Healthcare;Homeostasis;Individual;Intracellular Communication And Signaling;Investigation;Investments;Knowledge;Lead;Length Of Life;Link;Longevity;Mgc14458;Mr Imaging;Mr Tomography;Mri;Mt-Bound Tau;Magnetic Resonance Imaging;Magnetic Resonance Imaging Scan;Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance;Micro Rna;Micrornas;Modeling;Molecular;Molecular Fingerprinting;Molecular Interaction;Molecular Profiling;Monitor;Mononuclear;Nmr Imaging;Nmr Tomography;Neuritic Plaques;Neurofibrillary Tangles;Neuropsychologic Tests;Neuropsychological Tests;Non-Polyadenylated Rna;Noncoding Rna;Nontranslated Rna;Nuclear Magnetic Resonance Imaging;Origin Of Life;Oxidation-Reduction;Oxidative Stress;Pbmc;Pet;Pet Scan;Pet Imaging;Petscan;Pett;Psk-J3;Participant;Patients;Pb Element;Peripheral;Peripheral Blood Mononuclear Cell;Phase;Physiologic;Physiological;Physiological Homeostasis;Pilot Projects;Plasma;Plasma Serum;Positron Emission Tomography Medical Imaging;Positron Emission Tomography Scan;Positron-Emission Tomography;Primary Senile Degenerative Dementia;Printing;Production;Programmed Cell Death;Protein Family;Proteins;Psychologic Tests;Psychological Tests;Rna;Rna Expression;Rna Gene Products;Rad.-Pet;Redox;Repression;Research;Research Specimen;Resveratrol;Reticuloendothelial System, Serum, Plasma;Ribonucleic Acid;Risk;Sampling;Science;Screening Procedure;Senile Plaques;Serum;Signal Transduction;Signal Transduction Systems;Signaling;Societies;Specimen;Stress;Synapses;Synaptic;Testing;Transcription;Transcription Repression;Transcriptional Repression;Translations;Unscheduled Dna Synthesis;Untranslated Rna;Up-Regulation;Up-Regulation (Physiology);Upregulation;Work;Zeugmatography;Abnormally Aggregated Tau Protein;Advanced Age;Amyloid Beta Plaque;Amyloid Precursor Protein Processing;Amyloid-B Plaque;Balance;Balance Function;Base;Biological Signal Transduction;Biomarker;Calorie Restricted;Calorie Restriction;Cerebral Spinal Fluid;Cohort;Cored Plaque;Cyclin E2;Dementia Of The Alzheimer Type;Diffuse Plaque;Disease/Disorder;Drug Efficacy;Elders;Feeding;Filamentous Tau Inclusion;Foot;Gene Expression Signature;Gene Product;Gene Repression;Geriatric;Health Care;Heavy Metal Pb;Heavy Metal Lead;Indexing;Injury Response;Interest;Late Life;Later Life;Life Span;Lifespan;Meetings;Member;Mirna;Microtubule Associated Protein Tau;Microtubule Associated Protein Tau Aggregation;Microtubule Associated Protein Tau Deposit;Microtubule Bound Tau;Microtubule-Associated Protein Tau;Microtubule-Bound Tau;Molecuar Profile;Molecular Signature;Necropsy;Neurofibrillary Degeneration;Neurofibrillary Lesion;Neurofibrillary Pathology;New Diagnostics;Next Generation Diagnostics;Novel;Novel Diagnostics;Older Adult;Older Person;Over 65 Elderly;Oxidation Reduction Reaction;Paired Helical Filament Of Tau;Pilot Study;Polyphenol;Postmortem;Primary Degenerative Dementia;Protein Expression;Public Health Relevance;Red Wine;Repository;Response To Injury;Screening;Screenings;Self-Aggregate Tau;Senescence;Senescent;Senile Dementia Of The Alzheimer Type;Senior Citizen;Spinal Fluid;Success;Synapse;Tangle;Tau;Tau Phf;Tau Proteins;Tau Accumulation;Tau Aggregate;Tau Aggregation;Tau Factor;Tau Fibrillization;Tau Filament;Tau Neurofibrillary Tangle;Tau Oligomer;Tau Paired Helical Filament;Tau Polymerization;Tau-Tau Interaction;Tool;Transcriptome;Trend