SBIR-STTR Award

Development of an Electromyographically Controlled Electrolarynx Voice Prosthesis
Award last edited on: 4/10/19

Sponsored Program
STTR
Awarding Agency
NIH : NIDCD
Total Award Amount
$1,092,376
Award Phase
2
Solicitation Topic Code
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Principal Investigator
Mark A Robertson

Company Information

Griffin Laboratories Inc

27636 Ynez Road Suite L7199
Temecula, CA 92591
   (951) 695-6727
   sales@griffinlab.com
   www.griffinlab.com

Research Institution

Massachusetts General Hospital

Phase I

Contract Number: 1R41DC011212-01
Start Date: 9/1/10    Completed: 8/31/11
Phase I year
2010
Phase I Amount
$100,000
The most common artificial voice source for post-laryngectomy speech rehabilitation is the hand-held buzzer or electrolarynx (EL). This device is relatively easy to use and enables most laryngectomees to verbally communicate, but with reduced intelligibility and markedly degraded naturalness. In addition, EL speech is often described as robotic and monotone, attributable largely to the lack of normal fundamental frequency (F0) variation/control, abnormal voice source timing (e.g. voice onset and offset controlled by a thumb button) and abnormal spectral characteristics (e.g., reduced energy below 500 Hz). Previous research has demonstrated that neck surface electromyographic (EMG) signals can serve as an intuitive and effective control source for EL voice onset/offset timing and F0 modulation. The goal of this project is to develop an effective, practical, and user-friendly EMG-EL that can provide improved control over voice source timing and F0 for more intelligible and natural-sounding EL speech. The Phase I specific aims are 1) Produce a prototype wireless EMG sensor appropriate for EL control;2) Integrate wireless EMG signal reception and processing circuitry into a hand-held EL;and 3) Evaluate the prototype EMG-EL through testing with laryngectomy patients experienced in EL use. Assuming successful prototype development in Phase I, work in Phase II will further refine the EMG-EL by 1) Optimizing the control scheme of F0 and onset/offset from neck surface EMG signals;2) Determining which device parameters are appropriate for user adjustment which should be set by the clinician guiding speech rehabilitation;and 3) conducting extensive user testing of the device with iterative adjustment of its form and function based on user performance and structured feedback. , ,

Public Health Relevance:
The most common voice prosthesis used after total laryngectomy is the hand-held buzzer or electrolarynx (EL), but EL speech typically lacks pitch variation and precise timing control, giving it a highly unnatural sound quality with reduced intelligibility. Previous research has shown that pitch variation can significantly improve EL speech, and that neck muscle electromyographic (EMG) signals can be used as an intuitive control source for controlling EL vocal intonation and timing (onset/offset). The objective of this project is to develop and test an EMG-controlled EL that can be offered commercially to improve the communication and therefore lives of thousands of EL users.

Thesaurus Terms:
Address;Cell Communication And Signaling;Cell Signaling;Characteristics;Communication;Computer Systems;Consumption;Development;Devices;Electrodes;Electrolarynx;Feedback;Frequencies (Time Pattern);Frequency;Goals;Hand;Head And Neck, Larynx;Housing;Intracellular Communication And Signaling;Laboratories;Laryngeal;Laryngectomy;Larynx;Life;Manuals;Neck;Neck Muscles;Nervous;Patients;Performance;Phase;Physical Health Services / Rehabilitation;Pressure;Pressure- Physical Agent;Process;Production;Questionnaires;Rehabilitation;Rehabilitation Therapy;Rehabilitation, Medical;Research;Robotics;Scheme;Signal Transduction;Signal Transduction Systems;Signaling;Skeletal Muscle Structure Of Neck;Sound;Sound - Physical Agent;Source;Speech;Structure;Surface;System;System, Loinc Axis 4;Technology;Testing;Thumb;Thumb Structure;Time;Transducers;Variant;Variation;Voice;Voice Prostheses;Wireless Technology;Work;Base;Biological Signal Transduction;Computerized Data Processing;Cost;Data Processing;Experience;Improved;Neural;Pressure;Prototype;Public Health Relevance;Rehabilitative;Relating To Nervous System;Sensor;Signal Processing;Sound;Success;User-Friendly;Voice Box;Wireless

Phase II

Contract Number: 2R42DC011212-02
Start Date: 9/1/10    Completed: 4/30/15
Phase II year
2013
(last award dollars: 2014)
Phase II Amount
$992,376

The most common artificial voice source for post-laryngectomy speech rehabilitation is the hand-held buzzer or electrolarynx (EL). This device is relatively easy to use and enables most laryngectomees to verbally communicate, but with reduced intelligibility and markedly degraded naturalness. In addition, EL speech is often described as robotic and monotone, attributable largely to the lack of normal fundamental frequency (F0) variation/control and abnormal voice source timing (e.g. voice onset and offset controlled by a thumb button). Previous research has demonstrated that neck surface electromyographic (EMG) signals can serve as an intuitive and effective control source for EL voice onset/offset timing and F0 modulation. The goal of this project is to develop an effective, practical, and user-friendly EMG-EL voice prosthesis that can provide improved control over voice source timing and F0 for more intelligible and natural-sounding EL speech. In Phase I we achieved the following specific aims: 1) Produced a prototype wireless EMG sensor appropriate for EL control; 2) integrated wireless EMG signal reception and processing circuitry into a hand-held EL; and 3) evaluated the prototype EMG-EL through pilot testing with two laryngectomy patients experienced in EL use. In Phase II of this effort we will further refine the EMG-EL voice prosthesis by 1) testing the system with additional EL users both in the laboratory and though daily use with an at-home trial, 2) designing and building a new version of the EMG-EL prosthesis that can automatically adjust F0 range, onset/off thresholds, and EMG artifact rejection based on individual user's EMG signals, 3) testing the new system with EL users and performing perceptual assessment of their speech results by a large sample of listeners across a wide age range using an online interface, 4) application of visual and acoustic-based EMG biofeedback to improve EMG-controlled F0 modulation of vocal intonation, 5) conducting an extended at-home trial of the new EMG-EL system with EL users, and 6) creating a user guide and set of clinical instructions in preparation for EMG-EL system commercialization.

Public Health Relevance Statement:


Public Health Relevance:
The most common voice prosthesis used after total laryngectomy is the hand-held buzzer or electrolarynx (EL), but EL speech typically lacks pitch variation and precise timing control, giving it a highly unnatural sound quality with reduced intelligibility. Previous research has shown that pitch variation can significantly improve EL speech, and that neck muscle electromyographic (EMG) signals can be used as an intuitive control source for controlling EL vocal intonation and timing (onset/offset). The objective of this project is to develop and test an EMG-controlled EL that can be offered commercially to improve the communication and therefore lives of thousands of EL users.

Project Terms:
Acoustics; Address; Age; Algorithms; base; Certification; Charge; Clinical; commercialization; Communication; design; Development; Devices; diaries; Electrolarynx; electromyographic biofeedback; experience; Feedback; Frequencies (time pattern); Goals; Hand; Home environment; Hour; improved; Individual; Instruction; Laboratories; Laryngectomee; Laryngectomy; Manuals; meetings; Morphologic artifacts; Neck; Notification; Participant; Patients; Performance; Phase; Phase I Clinical Trials; Phase II Clinical Trials; Preparation; pressure; Process; Production; Prosthesis; prototype; public health relevance; Questionnaires; Rehabilitation therapy; relating to nervous system; Research; Robotics; Sampling; sensor; Signal Transduction; Skeletal muscle structure of neck; Skin; Small Business Technology Transfer Research; sound; Source; Speech; success; Surface; Surveys; System; Technology; Telephone Interviews; Testing; Thumb structure; Time; Training; usability; user-friendly; Variant; Visual; Voice; Voice Prostheses; Wireless Technology