The goal of the proposed research is to develop a personal exposure monitor for indoor and outdoor particulate matter in the ultrafine to 10 micron size range. The proposed device will collect large volumes of ambient air in the vicinity of the wearer's breathing zone and provide concentrated, size-classified samples for real-time analysis or for later analysis in a laboratory. This device will combine: (i) a novel aerosol concentrator to increase the particle concentration by up to three orders of magnitude, (ii) an aerodynamic size classifier to sort particles with sizes from 1 to 10 microns, and (iii) an electrostatic precipitator to capture and size classify particles smaller than 1 micron. The proposed monitor will provide the ability to couple the particle size classifier to a number of analytical assays (chemical or biological) that can be carried out in parallel. Combined with automated data recording and/or transmitting equipment and a GPS or other position-monitoring device, this monitor will be able to provide time- and space-resolved measurements of exposure to a wide range particulate matter. In the Phase I project-using advanced 3-dimensional, unsteady CFD methods-we will design a prototype of the aerodynamic particle size classifier, perform proof-of-concept experiments showing the feasibility of aerodynamic particle classification, and demonstrate nano-particle capture using an electrostatic precipitator. In Phase II we will combine the aerosol sampler/size classifier with a detection platform (possibly a microfluidic device) that can be used to carry out a variety of analyses on each size class in parallel.
Public Health Relevance: There is a growing awareness that exposure to complex environmental agents such as fine particulate matter can trigger or exacerbate diseases such as asthma and cardiovascular disease, however, there is still much uncertainty about the importance of specific chemical or physical factors and the causal relationship between disease and exposure. Standard aerosols collection and analysis methods cannot provide real time spatial and temporal resolution and often are often very labor intensive and non-specific. The proposed approach will overcome many of these difficulties by providing a very compact, light-weight, low-cost monitoring package that can be worn by an individual and, coupled to automated data recording and/or transmitting equipment and a GPS or other position-monitoring device, this personal exposure monitor will be able to provide time- and space-resolved measurements of a wide range of ambient aerosols.
Public Health Relevance Statement: Enertechnix, Inc. DHHS/NIH-NHLBI, Lung Deseases Topic C8 PHS 2008-2 Detection of Fine Aerosols Using a Novel Aerosol Sampler PROJECT NARRATIVE There is a growing awareness that exposure to complex environmental agents such as fine particulate matter can trigger or exacerbate diseases such as asthma and cardiovascular disease, however, there is still much uncertainty about the importance of specific chemical or physical factors and the causal relationship between disease and exposure. Standard aerosols collection and analysis methods cannot provide real time spatial and temporal resolution and often are often very labor intensive and non-specific. The proposed approach will overcome many of these difficulties by providing a very compact, light-weight, low-cost monitoring package that can be worn by an individual and, coupled to automated data recording and/or transmitting equipment and a GPS or other position-monitoring device, this personal exposure monitor will be able to provide time- and space-resolved measurements of a wide range of ambient aerosols. 8/5/2008 1 ivn:PR164 project narrative
Project Terms: 3-D; 3-Dimensional; Address; Aerosols; Air; Aspiration, Respiratory; Assay; Asthma; Awareness; Awarenesses; Bioassay; Biologic Assays; Biological; Biological Assay; Breathing; Bronchial Asthma; Caliber; Cardiovascular Diseases; Chemicals; Classification; Collection; Complex; Coupled; Coupling; Custom; Data; Detection; Development; Devices; Diameter; Diesel Exhaust; Disease; Disorder; Electrostatics; Elements; Endotoxins; Equipment; Exposure to; Fluorescence; Goals; Grant; Hour; In Situ; Individual; Inhalation; Inhaling; Inspiration, Respiratory; Laboratories; Lead; Liquid substance; Lung; Lung diseases; Measurable; Measurement; Methods; Methods and Techniques; Methods, Other; Microbiology; Microfluidic Device; Microfluidic Lab-On-A-Chip; Microfluidic Microchips; Monitor; National Institute of Environmental Health Sciences; Particle Size; Particulate; Particulate Matter; Pb element; Performance; Phase; Position; Positioning Attribute; Pulmonary Diseases; Pulmonary Disorder; Research; Resolution; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Sampling; Science of Microbiology; Security; Sorting - Cell Movement; Stream; Surface; System; System, LOINC Axis 4; Systematics; Techniques; Testing; Time; Toxicology; Ultrafine; Uncertainty; Universities; Washington; Work; base; cardiovascular disorder; cost; design; designing; detector; disease/disorder; doubt; environmental agent; experiment; experimental research; experimental study; fluid; heavy metal Pb; heavy metal lead; inspiration; instrument; lens; light (weight); light scattering; liquid; lung disorder; millimeter; monitoring device; nano meter; nano particle; nanometer; nanoparticle; novel; particle; prototype; public health relevance; pulmonary; research study; response; sorting; sub micron; submicron; ultrafine particle
