Calcium phosphate cements (CPCs) are used in orthopedic surgery as bone filler and have been proved with very good biocompatibility. However, the inadequate mechanical properties have significantly impeded their clinical applications despite of the good biocompatibility. Nanova Inc. is developing novel bone cement nanocomposites containing super-strong and ultra-long hydroxyapatite (HA) fibers. It is hoped that the novel calcium phosphate cement nanocomposites will have excellent biocompatibility as well as sufficient mechanical properties as a bone implant materials for many orthopedic applications, such as general bone grafts, prosthesis fixation, plateau fracture fixation, vertebroplasty and kyphoplasty, etc. The current prosthesis fixation using PMMA bone cements has a market of about $200 million. We believe that the calcium phosphate cements, if made strong and tough, will take over the current PMMA's market. Nanova Inc. estimated that the strong and tough calcium phosphate cements may have a market over $1 billion based on our marketing analysis. The strong and tough calcium phosphate cement nanocomposites will benefit the millions of patients world wide and will be a major contribution for the healthcare in the United States. The knowledge gained in this high-impact and innovative research will benefit research in other fields, such as hard tissue engineering and other non-biomedical nanocomposites.
Public Health Relevance: Nanova Inc. is developing calcium phosphate bone cement nanocomposites containing hydroxyapatite (HA) fibers with significantly improved mechanical properties. Such nanocomposites have the following orthopedic applications, such as general bone grafts, prosthesis fixation, plateau fracture fixation, vertebroplasty, and kyphoplasty, and they will benefit millions of patients with bone fracture.
Public Health Relevance Statement: Nanova Inc. is developing calcium phosphate bone cement nanocomposites containing hydroxyapatite (HA) fibers with significantly improved mechanical properties. Such nanocomposites have the following orthopedic applications, such as general bone grafts, prosthesis fixation, plateau fracture fixation, vertebroplasty, and kyphoplasty, and they will benefit millions of patients with bone fracture.
Project Terms: Affect; Biological; Biomimetics; Blood Plasma; Body Tissues; Bone; Bone Cements; Bone Glues; Bone Inflammation; Bone Pastes; Bone Transplantation; Bone and Bones; Bones and Bone Tissue; Caliber; Care, Health; Ceramic; Ceramics; Chemicals; Cytolysis; Development; Diameter; Fiber; Filler; Fixation; Foreign Bodies; Foundations; Fracture; Fracture Fixation; Grafting, Bone; Guidelines; Hand; Healthcare; Human; Human, General; Hydroxyapatites; Infection; Knowledge; Length; Life; Liquid substance; Lysis; Man (Taxonomy); Man, Modern; Marketing; Measurable; Mechanics; Methods; Mimetics, Biological; Minerals; Nature; Orthopedic; Orthopedic Surgery procedures; Orthopedic Surgical Profession; Orthopedics; Osteitis; PMMA; Patients; Phase; Plasma; Poly(methyl methacrylate); Polymers; Polymethyl Methacrylate; Polymethylmetacrylate; Polymethylmethacrylate; Property; Property, LOINC Axis 2; Prosthesis; Prosthetic device; Prosthetics; Research; Reticuloendothelial System, Serum, Plasma; Serum, Plasma; Skeletal Fixation; Solid; Surface; Surgery, Orthopedic; Technology; Tensile Strength; Testing; Thick; Thickness; Time; Tissue Engineering; Tissues; Tooth; Tooth structure; Toxic effect; Toxicities; United States; Work; base; biocompatibility; biomaterial compatibility; bone; bone fracture; calcium phosphate; chemical bond; clinical applicability; clinical application; cytotoxicity test; design; designing; engineered tissue; experience; fluid; implant material; improved; in vitro testing; innovate; innovation; innovative; liquid; nano composite; nano fiber; nano meter; nano meter scale; nano meter sized; nano scale; nanocomposite; nanofiber; nanofibrous; nanometer; nanometer scale; nanometer sized; nanoscale; novel; particle; public health relevance; sample fixation; teeth
