SBIR-STTR Award

Ontological Annotation for Cross-Scale Discovery
Award last edited on: 3/28/19

Sponsored Program
STTR
Awarding Agency
NIH : NIGMS
Total Award Amount
$109,118
Award Phase
1
Solicitation Topic Code
-----

Principal Investigator
John S Wassom

Company Information

Yahsgs LLC

3100 Geo. Washington Way Suite 103
Richland, WA 99352
   (509) 375-5359
   yahsgs@yahsgs.com
   www.yahsgs.com

Research Institution

Battelle Pacific Northwest Institute

Phase I

Contract Number: 1R41GM071983-01
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
2004
Phase I Amount
$109,118
User-friendly, intelligent, computer-based data mining tools are critical to fully realizing biomedical and toxicology researchers' effectiveness in uncovering knowledge contained in biomedical and toxicology databases and maximizing cross-scientific benefits. For example, continuing scientific advances are resulting in massive accumulations of macromolecular sequence data, most of which can not be effectively accessed by researchers. Further, toxicogenomic databases lack the ontology structures provided by the Gene Ontology making data searches laborious. This research sets forth innovative approaches designed to allow researchers to search across biomedical gene and toxicology ontology domains in free text using semantic similarity techniques. It will enhance cross-scale scientific discovery and facilitate effectively managing the exponentially growing research/clinical experience knowledge base. In Phase I we will demonstrate the feasibility of developing an automatic weighted cross-referencing tool for Gene Ontologies (molecular functions, biological processes, cellular components) using unsupervised learning techniques; illustrate cross-scale capabilities via a self-developed retrieval algorithm for discovering protein families; and building upon Phase I lessons learned and in-house experience, structure a toxicogenomic ontology strategy that facilitates cross-referencing Gene Ontology and toxicology databases. Phase II research will refine and expand the Phase I techniques to enable productive searches across all Gene Ontology domains and to develop prototype toxicogenomic ontologies. In Phase III the search tools will be brought to commercial readiness using traditional funding sources

Phase II

Contract Number: ----------
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
----
Phase II Amount
----