SBIR-STTR Award

The long-term objective of our project is to design, build, and market an ophthalmic instrument that simultaneously measures corneal topography and optical aberrations of the human eye using wavefront sensing technology. From these measurements our instrument will provide a complete description of the refractive properties of the anterior cornea, the whole eye, and (by inference the crystalline lens. This optical description will include not only the routine refractive errors of defocus and astigmatism normally measured by present-day optometers and corneal topographers, but will also determine the irregular, higher-order optical aberrations which characterize optically abnormal eyes. Feasibility of the aberrometer component of this dual instrument was proven in a previous STTR grant. The purpose of this Phase-I proposal is to demonstrate feasibility of the corneal topography component by building and testing a prototype instrument using core technology developed with previous STTR support. The major technological advantages of using wavefront sensing technology for corneal topography include: (1) improved performance compared to Placido disk technology, (2) novel assessment of the optical aberrations of the crystalline lens, (3) novel assessment of tear film and keratoconic irregularities, (4) space- and cost-effectiveness derived from application of a single core technology to replace multiple instruments. A combined topographer! aberrometer will help provide wavefront-guided prescriptions for aberration corrections based on inter-ocular lenses, corneal photo-ablative surgery, or contact lenses. The long-term benefits will be improved patient care through improved diagnosis and treatment of optical defects of eyes.

Thesaurus Terms:
biomedical equipment development, cornea disorder, diagnosis design /evaluation, eye disorder diagnosis, imaging /visualization /scanning cornea, corneal epithelium, lens, morphometry, ophthalmoscopy bioimaging /biomedical imaging, clinical research, human subject

The long-term objective of our project is to design, build, and market an ophthalmic instrument that simultaneously measures corneal topography, corneal aberrations, and whole-eye optical aberrations of the human eye using wavefront sensing technology. From these measurements our instrument will provide a complete description of the refractive properties of the anterior cornea, the whole eye, and (by inference) the crystalline lens. This optical description will include not only the routine refractive errors of myopia, hyperopia, and astigmatism normally measured by present day optometers and corneal topographers, but will also determine the irregular, higher-order optical aberrations that limit the quality of vision. This project is a joint venture of Wavefront Sciences, Inc. and Quarryment Optical, Inc. Our new, multipurpose instrument will be built around core technology of the Complete Ophthalmic Analysis System (COAS), a clinical whole-eye aberrometer currently marketed by Wavefront Sciences, Inc. In year I of this Phase II project we propose to add new functionallity to COAS for simultaneously measuring corneal topograhphy and corneal aberrometry. Quarrymen Optical, Inc. demonstrated feasibilty of such a multi-purpose instrument in Phase-I by building and validataing a prototype corneal topographer/aberrometer using core technology of a Shack-Hartmann wavefront sensor developed with previous STTR support. In year 2 we will experimentally validate and clinically evaluate our prototype instrument using clinically normal and abnormal human eyes. Our combined instrument will help provide wavefront-guided prescriptions for aberration corrections using inter-ocular lenses, corneal refractive surgery, or contact lenses. The long-term benefits will be improved patient care through improved diagnosis and treatment of optical defects of eyes.

Thesaurus Terms:
biomedical equipment development, clinical biomedical equipment, eye disorder diagnosis charge coupled device camera, computer data analysis clinical research, human subject