SBIR-STTR Award

The goal of this proposal is to develop a working framework for a multichannel data acquisition and stimulus presentation package for single-unit neurophysiology. In Phase I we will develop spike-sorting algorithms capable of discriminating action potentials from multiple neurons per each electrode, incorporating information across channels to improve the discrimination ability of the algorithm. Real-time discrimination would obviate the need for post-processing the data from high channel count systems, improving the ability to make experimental decisions during the course of the experiment. We will also develop a graphical display and interface designed to condense the inherently complex data sets that are acquired simultaneously from many single-units across many electrodes and stimulus parameters. The combination of stimulus control with multichannel acquisition will similarly improve data visualization. PROPOSED COMMERCIAL APPLICATION: The proposed project is to test the feasibility of developing a high channel count system for neurophysiology research. The commercial application of this product is most directly for the scientific research market in multichannel neurophysiology. It could be adapted for other clinical systems that require high channel counts, such as EEG systems.

The goal of this proposal is to continue the development of a multichannel data acquisition and stimulus presentation package for single-unit neurophysiology. New interfaces and development tools will be created to help investigators harness the flexibility of the Phase I software. Continuing development of real-time digital signal processing (DSP) algorithms for multichannel spike processing will be carried out, exploiting the real-time capabilities of TDT's System 3 hardware. Finally, powerful new post-processing routines for multichannel spike sorting and analysis will be incorporated. The fundamental advantage of this system is its flexibility and extensibility. The adaptable platform allows for virtually any signal type to be presented and acquired. Multichannel single unit, local field potentials, EEG, EMG, vocalizations, sensor data, etc. can be acquired and integrated into a single data structure. Acquisition and stimulation are controlled through a single integrated software package, and through a set of synchronized hardware modules. The integration of real-time experimental control and stimulus delivery in the same system as multi-channel data acquisition and analysis allows for dynamic experimental control and stimulus modification based on neural or behavioral responses.

Thesaurus Terms:
action potential, biomedical equipment development, computer program /software, computer system design /evaluation, electrophysiology, neurophysiology, sensory mechanism computer graphics /printing, computer human interaction, electrode, electroencephalography, electromyography