SBIR-STTR Award

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Fluor Indicator Dyes for Extracell Ions
Award last edited on: 3/2/21

Sponsored Program
SBIR
Awarding Agency
NIH : NICHD
Total Award Amount
$933,658
Award Phase
2
Solicitation Topic Code
-----
Principal Investigator
Michael A Kuhn

Company Information

Helix Research Company

1940 Don Street Suite 280
Springfield, OR 97477
   (541) 988-0464
   N/A
   N/A
Location: Multiple
Congr. District: 04
County: Lane

Phase I

Contract Number: N44HC015194-000
Start Date: 12/20/00    Completed: 10/31/02
Phase I year
2001
Phase I Amount
$512,502
To develop fluorescent indicator dyes for the utilization of optical methods to determine airway surface liquid and other fluid composition by measurement of the emission of fluorescent indicator dyes for Na or Cl covalently attached to a large dextran molecule or latex bead. The ion indicators must change their fluorescence emission or absorption in proportion to alterations in the Na or Cl concentration of extracellular fluids, concentrations of about 150 mM. The indicator dyes should be excited by visible wavelength light, be water soluble, non-toxic, and minimally affected by the presence of proteins

Phase II

Contract Number: N44HC015194-000
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
2001
(last award dollars: 2002)
Phase II Amount
$421,156
___(NOTE: Note: no official Abstract exists of this Phase II projects. Abstract is modified by idi from relevant Phase I data. The specific Phase II work statement and objectives may differ)___ To develop fluorescent indicator dyes for the utilization of optical methods to determine airway surface liquid and other fluid composition by measurement of the emission of fluorescent indicator dyes for Na or Cl covalently attached to a large dextran molecule or latex bead. The ion indicators must change their fluorescence emission or absorption in proportion to alterations in the Na or Cl concentration of extracellular fluids, concentrations of about 150 mM. The indicator dyes should be excited by visible wavelength light, be water soluble, non-toxic, and minimally affected by the presence of proteins