SBIR-STTR Award

Presentation: Precision PC Stimulation For Neuroscience
Award last edited on: 3/5/07

Sponsored Program
SBIR
Awarding Agency
NIH : NINDS
Total Award Amount
$923,034
Award Phase
2
Solicitation Topic Code
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Principal Investigator
Peter A Pebler

Company Information

Neurobehavioral Systems Inc (AKA: NBS)

15 Shattuck Square Suite 215
Berkeley, CA 94704
   (510) 527-9231
   N/A
   www.neurobs.com
Location: Single
Congr. District: 13
County: Alameda

Phase I

Contract Number: 1R43NS040623-01
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
2000
Phase I Amount
$122,175
Continued advances in our understanding of brain function depend on the presentation of increasingly complex and realistic stimuli. Current stimulus delivery systems are inadequate for this task -- they are expensive, generally DOS-based, and inflexible in the types of stimuli that they can deliver. We have developed an easy-to-use Windows95/98 program, Presentation, that takes advantage of the DirectX gaming functions of Windows to deliver complex stimuli and monitor responses with sub-ms temporal precision. It can deliver auditory, visual or multimodal stimuli and simultaneously monitor responses without special hardware. It incorporates a "TimeVerify (TV)" feature that reports the temporal uncertainties as well as the time of occurrence of all events, assuring a valid timing record under all conditions. In Phase I, we will make further improvements in Presentation including (1) Device drivers to monitor responses using hardware interrupts; (2) Tools to simplify the creation of Presentation-based experiments; (3) A library of ready-to-run examples of classic experiments; and (4) Extensive benchmark testing and documentation of Presentation performance. Throughout, we will work closely with collaborating laboratories expert in fMRI, ERP and behavioral experimentation to optimize Presentation for these demanding applications PROPOSED COMMERCIAL APPLICATION: The proposed activity will lead directly to the production of a commercial software package for the presentation of stimuli in psychology and neuroscience experiments.

Phase II

Contract Number: 2R44NS040623-02
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
2001
(last award dollars: 2002)
Phase II Amount
$800,859

Precise and flexible stimulus delivery and experimental control (SDEC) are essential for studies of perception and higher-cognitive functions. We have developed Presentation, a Windows SDEC program that delivers complex multimodal stimuli and monitors responses with precise timing. We now request Phase II support to add innovative new features to Presentation including (1) Adaptive stimulus delivery using the Presentation Control Language (PCL). PCL permits stimuli to be altered in real time based on performance or physiological responses, allowing automated adjustments in task difficulty, computer-controlled determination of neuronal receptive fields, and frame-by-frame display control important for computer-based neuro-rehabilitation. ((2) Graphic and audio stimulus generation using high-level Direct3D and DirectSound commands. These will permit auditory and visual stimuli to be defined and manipulated in 3D space. Stereovision and tactile stimulation capabilities will also be added sing DirectX 8.0 utilities. (3) A stimulus generation module interface (SGMI), permitting user programs to present custom stimuli during Presentation experiments. (4) Real-time streaming video with precise frame-by-frame control, making possible experiments with digitized and synthesized video sequences; (5) Easy-to-use tools for experiment creation and analysis to facilitate the development and analysis of experimental protocols. These additions will make Presentation an unexcelled SDEC platform for Phase III product launch. PROPOSED COMMERCIAL APPLICATION: Te proposed project will lead directly to a commercial PC-based stimulus delivery / experimental control software package.