Implantable Pressure, Flow & ECG Telemetry for Animals
Award last edited on: 3/5/07

Sponsored Program
Awarding Agency
Total Award Amount
Award Phase
Solicitation Topic Code

Principal Investigator
Perry A Mills

Company Information

Data Sciences International (AKA: Transoma Medical)

119 14th Street Nw Suite 100
St. Paul, MN 55112
   (651) 481-7400
Location: Multiple
Congr. District: 04
County: Ramsey

Phase I

Contract Number: 1R43HL062803-01A1
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
Phase I Amount
Implantable telemetry has progressed substantially over the past decade, with innovative devices being developed for monitoring heart rate, blood pressure, and other key functions in laboratory animals. These devices have allowed researchers to make great strides toward more-humane animal testing, reduced animal use, and improved efficiency and research quality. To date, however, one important aspect of cardiovascular monitoring has not been addressed: blood flow. In this project, the feasibility of a complete system for telemetric monitoring of blood pressure, ECG, and blood flow in conscious, freely moving animals larger than about 3 kg will be evaluated. The system will consist of novel, battery-powered implantable devices, receivers to pick up the telemetered signal; and a data-acquisition system to collect, store, and analyze the data. Key to success of this effort is to establish the feasibility of a novel approach to power reduction that, according to pilot evaluations, appears to be capable of reducing current drain by a factor of 15 or more over the best designs currently available. Phase 1 success will lead to a Phase II project designed to produce a prototype system. We believe that further improvements upon the Phase II design will make this technology viable in the much larger human clinical market. PROPOSED COMMERCIAL APPLICATIONS: Successful completion will result in a valuable new tool for biomedical researchers. In addition, the technology developed here has significant potential for human use once performance is improved in later generation designs.

Phase II

Contract Number: 2R44HL062803-02
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
(last award dollars: 2001)
Phase II Amount

Data Sciences International (DSI) is developing an implantable battery powered flow meter-telemetry system for use in chronically instrumented animals. The transit time flow meter signal is telemetered at 2 MHz, while the simultaneously implanted telemetry system for blood pressure and ECG uses 455 kHz. This phase 2 application is buttressed by results of phase 1 that have accomplished specified goals regarding battery life, accuracy and reproducibility, freedom from interference and implantability