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SBIR-STTR Award
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SBIR-STTR Award
10
Assay For Antibacterials Affecting Initiation Factor 3
Award last edited on: 7/1/08
Sponsored Program
SBIR
Awarding Agency
NIH : NIAID
Total Award Amount
$99,998
Award Phase
1
Solicitation Topic Code
-----
Principal Investigator
Carol S Dammel
Company Information
Questcor Pharmaceuticals
(
AKA
: Ribogene Inc~Cypros~Transgene~NeuroTherapeutics)
3260 Whipple Road
Union City, CA 94587
(510) 400-0700
sales@questcor.com
www.questcor.com
Location:
Multiple
Congr. District:
15
County:
Alameda
Phase I
Contract Number:
1R43AI044523-01
Start Date:
00/00/00
Completed:
00/00/00
Phase I year
1999
Phase I Amount
$99,998
New antibiotics are desperately needed as clinically significant bacterial pathogens have acquired resistance to nearly all existing antibiotics. We describe a high-throughput screening system for identifying new antibacterial agents specifically targeted against an integral component of the bacterial translation apparatus. Work described in this application will identify compounds that selectively inhibit the bacterial initiation factor IF3. We propose to implement a primary screening assay to identify inhibitors of E. coli IF3. The assay uses a reporter fusion system in whole cells and is a parodoxical growth assay. Inhibitors of IF3 are expected to result in increased growth of cells due to higher levels of expression from the reporter gene. Following the primary assay a series of in vitro secondary assays designed to confirm that inhibitors target IF3 function will be performed. Reporter constructs analogous to those used in the primary screening assay will be used in in vitro translation reactions to determine the exact nature of IF3 inhibition. Finally, positive compounds will be evaluated for antibacterial efficacy and for toxicity in mammalian cells. PROPOSED COMMERCIAL APPLICATIONS: This research will develop a new assay to identify novel antibacterial drugs for treating bacterial. infections
Phase II
Contract Number:
----------
Start Date:
00/00/00
Completed:
00/00/00
Phase II year
----
Phase II Amount
----
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