SBIR-STTR Award

Probe Of Regional Lung Function Using Light Scattering
Award last edited on: 2/25/02

Sponsored Program
SBIR
Awarding Agency
NIH : NHLBI
Total Award Amount
$92,780
Award Phase
1
Solicitation Topic Code
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Principal Investigator
James P Butler

Company Information

Biomechanics Institute Inc

25 Bay State Road
Boston, MA 02215
   N/A
   N/A
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Location: Single
Congr. District: 07
County: Suffolk

Phase I

Contract Number: 1R43HL055032-01
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
1996
Phase I Amount
$92,780
There is now a resurgence of interest in surgical therapy for emphysema, a debilitating disease affecting 1.65 million Americans, almost half of whom are over 65, at an annual cost of over $4 billion. During lung reduction surgery poorly functioning, hyper-expanded lung regions are resected in order to allow less diseases lung to reexpand, restoring lung recoil, ventilatory mechanics, and gas exchange back towards normal. Currently, surgeons are limited in their ability to differentiate the most diseased lung regions from more normal areas; i.e. what to resect and what to leave in place. This proposal involves the design, fabrication, and testing for feasibility of an optical dual-wavelength diagnostic probe of regional lung function that can be used in the operating room. This will be done by exploiting the diffuse scattering nature of the optical properties of the lung. This diffuse character makes standard oximeters unsuitable and requires the novel technological approaches outlined in this proposal. The device will provide indices of the regional variability of surface to volume ratios, capillary blood volume, and oxygen saturation.Proposed commercial application:Emphysema is a debilitating disease affecting 1.65 million Americans. Surgical therapy is being increasingly used in its treatment. There is the potential for tens of thousands of such operations each year in the United States alone, and our device and technique for intra-operative assessment of regional lung function would represent a substantial adjunct to all such procedures.National Institute of Heart, Lung, and Blood Institute (NHLBI)

Phase II

Contract Number: ----------
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
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Phase II Amount
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