SBIR-STTR Award

Laser Device For In-Situ Monitoring Of Crystallization
Award last edited on: 4/25/2002

Sponsored Program
SBIR
Awarding Agency
NIH : NIGMS
Total Award Amount
$90,123
Award Phase
1
Solicitation Topic Code
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Principal Investigator
Amir A Naqwi

Company Information

TSI Inc

500 Cardigan Road
Shoreview, MN 55126
   (612) 483-0900
   cfox@tsi.com
   www.tsi.com
Location: Multiple
Congr. District: 04
County: Ramsey

Phase I

Contract Number: 1R43GM054476-01
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
1996
Phase I Amount
$90,123
Phase Doppler measurement technique (originally developed for spherical particles) will be adapted to localized in-situ measurement of size and size-velocity correlations of crystals during their growth. During Phase I, feasibility of extending this interferometric technique to irregular particles will be examined. So far, only regular (mainly spherical) particles have been measured by the above instrument, using phase shift signals as a deterministic measure of the particle size. For irregular particles, the phase signals will be interpreted as an outcome of a stochastic process. This project aims at experimentally examining the nature of the phase shift probability functions, associated with crystals (preliminary measurements indicate that these functions may be fairly simple in form). For this purpose, besides the in-situ phase Doppler measurements, samples of crystals under investigation will be taken at different stages of the crystallization process and their size distributions will be qualified using an off-line sieving technique. The theory of geometrical scattering by statistically random particles will also be used to predict the above probability functions. Finally, numerical inversion schemes will be employed to deduce velocity-resolved crystal size distributions from the measured phase shift distributions.PROPOSED COMMERCIAL APPLICATIONS: The successful completion of Phase II will lead to a very desirable technique for non-intrusive and spatially- resolved measurement of crystals during their growth. The results would be used for optimizing crystallizer design as well as regulating the crystal growth process using a feedback controller.National Institute fo General Medical Sciences (NIGMS)

Phase II

Contract Number: ----------
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
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Phase II Amount
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