Some nitrone spin traps have been found to possess many potentially useful pharmacological propertilowering septic shock fatality, reversing the effects of aging, cardioprotection, and vasodilation.dispositon and metabolism in the development of these compounds as new drugs require the nitrone comwith carbon-14. We will develop the preparative steps for a-phenyl-N-t-butylnitrone-a-14 C, 5,5-dimeoxide-a-14 C, and 4-bromomethylpyridine-a-14 C which is a precursor to a-(4pyridyl-1-oxide)-N-t-butyPhase II will complete the synthesis of 4-POBN-a-14C and pursue the 14C-labeled versions of other pr.
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