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SBIR-STTR Award
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SBIR-STTR Award
10
Photo-Linked Antibody Chelates for Tumor Imaging
Award last edited on: 3/20/02
Sponsored Program
SBIR
Awarding Agency
NIH : NCI
Total Award Amount
$75,000
Award Phase
1
Solicitation Topic Code
-----
Principal Investigator
Beby Jayaram
Company Information
Immpheron Inc
1501 Bull Lea Suite 105
Lexington, KY 40511
(859) 277-9404
info@immpheron.com
www.immpheron.com
Location:
Single
Congr. District:
06
County:
Fayette
Phase I
Contract Number:
1R43CA065299-01A1
Start Date:
00/00/00
Completed:
00/00/00
Phase I year
1995
Phase I Amount
$75,000
Light induced chemical reactions (so called photochemical activation) can be done under mild conditions which are physiological for biologically active macromolecules. We have recently used such photo-chemistry to attach small organic molecules to antibodies. The photolinker contain side chains which can act as chelaters for metals. The aim of this proposal is to use this technique to produce radiolabeled antibodies for tumor imaging through photoincorporation of chelated 111Indium3+. Preliminary experiments showed that the photolinker attaches in a specific fashion to a discrete site on immunoglobulins of different isotopes and specificities. Furthermore, it was demonstrated that photolinked antibodies retain the full capacity to bind to antigen. In the present proposal we plan to produce radiolabeled anti-tumor antibodies against a mouse and a human B cell lymphoma cell line and to use these radiolabeled antibodies to image tumor in situ by scintigraphic techniques. We expect to show that our photoactivation technique will produce radiolabeled antibodies against cancers with superior tumor-uptake specificity. Such radiolabeled antibodies are much needed and valuable tools for cancer diagnosis and therapy.National Cancer Institute (NCI)
Phase II
Contract Number:
----------
Start Date:
00/00/00
Completed:
00/00/00
Phase II year
----
Phase II Amount
----
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