Blood glucose monitoring is a technique that is widely applied in current diabetes care. It gives the patient a timely estimate of blood glucose upon which changes in their management can be made. The current method, which requires some source of lancet induced blood sample, is somewhat inconvenient and entails considerable cost. These factors limit the frequent application of this technique by all diabetic patients. Therefore a non-invasive method of blood glucose determination that would be convenient, fast, and not require a blood sample could have significant widespread application for diabetes management. The objective of this application is to develop a near-infrared based noninvasive glucose meter which fulfills current requirements of self blood glucose monitoring. Tight control of blood glucose is capable of reducing the devastating complications of diabetes. Attaining normal blood glucose is a tremendous undertaking for a diabetic patient and the development of a noninvasive glucose meter will significantly reduce barriers to achieving this goal.National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)