Daily use of a sonic toothbrush has been shown to significantly reduce supragingival plaque, subgingival bacterial and periodontal pocket depth. The primary objective of the current application is to further enhance the efficacy of the sonic toothbrush. Laboratory evaluation of various design iterations will be conducted with in vitro assays. This approach may provide high potential for improved oral health, for both the general population and those with periodontal diseases.National Institute of Dental Research (NIDR)