We will develop an innovative technique of applying an adhesive-backed membrane directly to the lid of and check below the dominant eye that facilitates regeneratlon and homing of optic nerve fibers in the non-dominant eye of young children with amblyopia strabismus. We have developed a class of novel medical adhesives that exhibit a dramatic reduction in peel strength upon warming above some designated switch temperature. This feature permits the direct application to the stratum corneum (and hair) surrounding the eye. This switch temperature will be tailored to occur within the narrow temperature limit between external body temperature and safely below the tissue damage temperature thereby reducing the physical and mental trauma associated with medical adhesive removal and improving patient compliance with the treatment methodology.Awardee's statement of the potential commercial applications of the research:An effective medical adhesive that allows a significant reduction in trauma associated with medical films and wound care product removal is expected to find application in wound closure, medical drape, medical dressings and bandage products.National Eye Institute (NEI)
