This project will explore the development for neurophysiology of an advanced multiple spike train data acquisition and analysis workstation, based on Intel 80486 computer with Windows-NT operating system, for data storage, data handling and comprehensive data analysis. The station will include provisions for input of data in several existing formats, database management and elaborate data sorting for a variety of experimental protocols, and for a wide range of graphical displays and statistical analyses of single and multiple spike trains. A need for this research toward product development has arisen since recent technical advances now allow routine experimental acquisition of many concurrently recorded neurons in awake behaving animals. There are three major aims of this proiect: I) to prepare a manual for user documentation and on-line help files in an advanced Windows interface, 2) to include a program feature allowing flexible sorting of data within sessions and across sessions, and 3) to evaluate use of Windows-NT for rapid update and support of programs nationally through the Internet network system.Awardee's statement of the potential commercial applications of the research:This project will analysis techniques currently not available. Neurophysiology laboratories m both university and industrial settings could profit substantially by commercial availability of this analysis. Clinical applications in neurology and psychoTogy may be demonstrated.National Institute of Neurological Disorders and Stroke (NINDS)