Radioactive thallium is used in an important method for diagnosing coronary artery, ischemic heart disease, and related cardiac disorders. Radioactive imaging with 20 1T1 is the most frequently employed method for myocardial imaging; radioactive imaging with 1T1 aids in visualizing the blood flow to the various regions of the left ventricular myocardium. High quality 1T! is produced using the enriched stable isotope 203T1, which is increasingly less available. Recent developments in high resolution laser photoionization using new solid state continuous wave laser technology permit the highly selective enrichment of the minor isotope 203T1 in natural thallium. The successful development of this technology would assure a stable and reasonably priced supply of 203T1 to support 201T1 radioactive imaging needs. The specific aims of this project are to develop a modified thermal atomization thallium source, investigate the photoionization spectroscopy of 203T1, and to determine the potential for isotopically selective ionization and enrichment of 203T1.Awardee's statement of the potential commercial applications of the research: Commercial potential includes a currently substantial and expanding market for the sale of 203-thallium for radioisotope production and imaging.National Heart, Lung and Blood Institute (NHLBI)
