The long term objectives are to generate antibody catalysts for therapeutic applications. Specificallv we will prepare antibody catalysts to inactivate the AIDS virus and to deliver anti-tumor drugs to tumor sites for the treatment of cancer. Subsequent commercialization will include the development of therapies for other viral diseases and the preparation of detoxification agents. The therapeutic catalytic antibodies will be prepared by synthesizing specific haptens and raising antibodies to antigens derived from these haptens. A new approach to the design of these haptens involves the use of aminophosphinic acids and is based on an analysis of enzyme mechanisms.Awardee's statement of the potential commercial applications of the research: The potential commercial applications for this research are preparation of therapeutic antibodies for the treatment of most viral diseases, such as AIDS, a new cancer therapy involving specific delivery of a toxic drug to a tumor site, generation of detoxification agents for treatment of drug overdose in vivo, and methods to supplement enzyme deficiencies.National Institute of Allergy and Infectious Diseases (NIAID)
