Advances in the neurosciences have resulted in a better understanding of the pathophysiology of many disorders of the human central nervous system (CNS). Likewise, computed tomography and magnetic resonance imaging now provide high anatomic resolution of CNS structures. Intervention in many CNS diseases is hindered however, by physical constraints such as the blood-brain barrier, the unique nature of functions within the brain, and the sensitivity of the brain to surgical manipulation. This research combines advances in neurosciences and imaging, with computer science and superconductivity to test a device designed to overcome the physical barriers to the treatment of CNS disorders. This device, the Magnetic Stereotaxis System, magnetically manipulates a small metallic seed through the brain parenchyma to deliver highly targeted therapy for diseases such as malignant brain tumors, epilepsy or Parkinson's disease. A surgeon guides the seed using real-time imaging of seed movement displayed on previously obtained stereotactic magnetic resonance images. This research will: (1) calibrate the imaging and stereotaxis system, (2) magnetically manipulate a seed in a brain phantom, and (3) magnetically manipulate a seed-catheter array in a brain phantom.Awardee's statement of the potential commercial applications of the research:Potential commercial application of the device will be in the treatment of CNS disorders such as malignant brain tumors, epilepsy or Parkinson's disease, and possibly other diseases of the CNS.National Cancer Institute (NCI)
