Intraocular hyperthermia, IHT, is being investigated as an adjunct to ionizing radiation therapy as a means of improving therapeutic response while minimizing undesired side effects. For microwave, radio frequency or ultrasound inducing IHT it has been difficult to localize such heating to the tumor tissue. We will develop a system for intraocular laser induced hyperthermia, ILHT. Emphasis in Phase-I is to develop the necessary delivery systems and testing of them in an appropriate animal model. The system is to include both a transcomeal approach and a transcleral approach. The laser to be used is the 1064nm NDYAG due to its deep penetration in tissue. The delivery systems will emphasize the ability to irradiate a large area >I.Ocinindia meter, with uniform irradiance. Testing is to be done in rabbits with and without transplanted choroidal tumors. Testing in Phase I will include on line thermal monitoring in the animal systems along with thermal modeling of the response. Limited results to date by Gomer and Svaasand, with crude delivery devices, have been promising. If the proper delivery devices and overall system can be developed ILHT could find a significant use in the management of intraocular tumors in combination with other therapies. Its commercial potential could be significant if it can be made cost effective and easy to use, which is the specific aim of this project.Awardee's statement of the potential commercial applications of the research:The commercial potential of the system could be significant if it is cost effective and easy to use. In addition to the 2,000 annual new cases who could potentially benefit from such a system, there is an additional 4,000 to 8,000 patients with existing ocular tumors being followed that could also be treated. In combination with the international market it is estimated the potential market for such a system would be approximately 250 systems on a conservative basis.National Eye Institute (NEI)
