Development of a new DNA sequencing instrument
Award last edited on: 3/20/02

Sponsored Program
Awarding Agency
Total Award Amount
Award Phase
Solicitation Topic Code

Principal Investigator
Edward D Hyman

Company Information

Bayou Biolabs (AKA: Sybtrel Biotechnology)

4724 Hessmer Avenue
Metairie, LA 70002
Location: Single
Congr. District: 01
County: Jefferson Parish

Phase I

Contract Number: 1R43GM044011-01
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
Phase I Amount
The objective of this project is to develop a DNA sequencing instrument utilizing the pyrophosphate-based method of DNA sequencing. This is a new method that does not use electrophoresis, radioactivity, or fluorescence. The method works by measuring pyrophosphate generated by the DNA polymerization reaction. The pyrophosphate is measured continuously by a device consisting of a series of columns containing enzymes covalently attached to a solid support. Phase I will be devoted to solving the remaining biochemical problems associated with the method. If the method is demonstrated to work well enough, Phase II will consist of construction of a prototype instrument suitable for large-scale production.

Anticipated Results:
A DNA sequencing instrument will be useful in all fields of medical and biological research. DNA sequencing is a pivotal technique that is vital to modern research. Currently available instruments and manual techniques are laborious and expensive. This instrument is based on a new process that will offer increased automation and cost less.National Institute Of General Medical Sciences (NIGMS)

Phase II

Contract Number: ----------
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
Phase II Amount