The proposed project is to create a data bank containing information on MoAbs used in diagnostic and therapeutic clinical trials. A three-tiered system is proposed: a bibliographic reference file of literature citation and abstracts for MoAbs with clinical applications; a background file on developers, distributors, availability, and characteristics of the hybridomas and other cloned cell lines producing immunoreagents of clinica significance; and a relational file of data on materials, methods and results of clinical trials with MoAbs. The data bank will be designed for easy use on microcomputers and commercially available software by noncomputer professionals and it will be widely disseminated to the biomedical community.National Cancer Institute - Department of Cancer Treatment (NCI-DCT)