SBIR-STTR Award

The cardiovascular system is an integrated system where the performance of each part of the system depends on the characteristics of all other parts of the system. However, the function of the components of the cardiovascular system are taught individually. For example, cardiac performance may be presented in terms of dp/dt, ejection fraction, or functions curves, while vascular beds are studied in terms of compliances or steady state resistance. The studen cannot easily reconcile these representations into a whole system understanding. A mathematical model has been developed that characterizes the chambers of the heart and the vascular beds in terms of instantaneous pressures, volumes, and flows. This approach has been used to develop computer simulations for teaching medical physiology. These tools have been found to improve student understanding of the cardiovascular system. However, these phototypes are not complete enough or easy enough for a physician to use as a cardiology teaching tool. We propose to develop a computer simulation for teaching cardiology that would have: 1) simulations of the isolated left heart and the integrated cardiovascular system; 2) an environment for re-creating the natural history of diseases; 3) a practice environment where students diagnose cardiovascular problems.

This project will create an integrated set of microcomputer simulations of cardiovascular (CV) function covering introductory hydraulics, systemic circulation, cardiac anatomy, isolated heart and CV system performance, cardiac pathologies, introduction to reflexes, electrocardiogram, CV pharmacology, and cardiac imaging. Ten simulations, together with accompanying texts and problem sets, will allow undergraduates, medical students, cardiology trainees, and allied health professionals to develop an understanding of CV physiology at the organ system level. Materials will be indexed by subject and difficulty. Students will: (1) simulate physiology experiments on all components of the CV system independent of other components, (2) connect components to simulate the interactions of the integrated CV system, (3) add reflex mechanisms to simulate a controlled system, (4) create pathologies in any of the components, and (5) administer drugs in normal and pathologic situations. Program displays will show CV function in common clinical manners: hemodynamic data, electrocardiogram, and cardiac images. Each module of the package will include a simulation, a monograph, problem sets, and individualized learning assessment tools. These materials will offer alternatives to live animal experimentation.

Anticipated Results:
This project will develop computer-assisted learning materials in CV function appropriate for use by students in medicine, dentistry, physiology, pharmacology, veterinary medicine, nursing, physical therapy, medical technology, and biology. The price to students for all software and print materials will not exceed the cost of a textbook.National Heart, Lung, And Blood Institute (NHLBI)