SBIR-STTR Award

Recently developed eye-movement analysis software with improved noise-rejection and more general applicability than comparable previously published software, will undergo first-stage clinical testing and further development. From a normal population, hand and computer measurements of cqioric and spontaneous/positional nystagmus will be compared. Also, across- and within-subject groups variabilities of new measurements of caloric response intensity analyzed by computer will be compared with standard hand measurements. Clinical data will be collected to assess improvement in test sensitivity achieved by the new computer measurements of caloric response sensitivity. Further development and refinement of software and interface hardware will proceed in parallel with the clinical study. The ultimate objective is to create a low-cost, easy-to-operate, general-purpose clinical vestibular and oculomotor test system which will use the new eye-movement analysis software as basic building blocks.National Eye Institute (NEI)

Eye-movement analysis software employing new algorithms has been successfully tested in Phase I for its ability to automatically quantify caloric, rotational, smooth pursuit and optokinetic tests in routine clinical use. In the Phase II project, some refinements in the basic algorithms suggested by results of the Phase I work will be implemented, the capabilities of the system will be expanded to include the saccade velocity and rotation tests, clinical trials comparing the sensitivity achieved by a computer and hand measurements in quantifying the caloric test to detect peripheral vestibular pathology will be completed, and development of software and hardware necessary to commercialize the system will be undertaken. The ultimate objective of the project is to create a low-cost, easy-to-operate, general-purpose clinical vestibular and oculomotor test system based on the new eye-movement analysis software.

Thesaurus Terms:
Biomedical Engineering, Instrumentation Clinically Oriented Biomedical Systems Automated, Computer Assisted Diagnosis Biomedical Systems Automated, Computer Processing Of Clin Computer Computer, Design And Evaluation Of Computers (Incl. Hardware) Computer Programming Diagnostic Tests, Design, Development And Evaluation Of Diagnostic Tests Eye Disorders Diagnosis, Electrooculography Eye Disorders Diagnosis, Nystagmography, Electronystagmography Eye Movement And Coordination Disorders, Eye Movement Dis Eye Movement And Coordination Disorders, Nystagmus Eye Movements Human, ClinicalNational Eye Institute (NEI)