This study is designed to develop and evaluate a method of replacing a hollow viscus with a prosthesis that allows primary mucosal healing and incorporation of the prosthetic into the healing process.Healing of a full thickness isolated bowel segment to 2 types of a hollow viscus prothesis will be evaluated in dogs. Both types of prosthesis will consist of an outer rigid mesh and a biodegradable middle layer. The Type A prosthesis will have an inner impervious layer, the Type B prosthesis will not. The prostheses will be evaluated at various postimplantation times of up to and including 60 days. Evaluation of healing patterns of the prostheses and mucosal regeneration, infection, connective tissue ingrowth, rejection, and stricture will be performed by gross exam and light microscopy.
Thesaurus Terms: Biomaterials, Biomaterials Evaluation, Biomaterials, Development And Preparation Of Biomaterials, Gastrointestinal Prosthesis, Prosthesis Biomaterials, Biomaterials, Interfacial Phenomena, Biomaterials, Tissue Supporting Frames, Fibrous Proteins, Collagen, Gastrointestinal Surgery, Intestinal Surgery, Gastrointestinal System, Intestines, Mucosa, Injuries, Wound Healing, Metabolism, Biotransformation, Plastics, Polyurethanes, Plastics, Silicone Rubber, Prosthesis Implants And Compatibility Histology (General), Mammals, Carnivores, Dogs, Optics, Microscopy (General), Optics, Microscopy, Electron National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)