The long term objective of the project is to develop an automated, simple to use system for the measurement of respiratory mechanics in newborns and children with a passive expiratory maneuver. Flow volume measurements following relaxation of the respiratory muscles with the Hering-Breuer reflex allows for calculation of total compliance and resistance using the end inspiratory plateau pressure as mean pleural pressure. Previously described application of this technique used manual controls for shutter closure and data analysis, excluding the method to only research applications. Special design considerations have provisions for managing the low deadspace requirements of the patient population and producing airway occlusion without inducing pressure artifacts. An automated system would place this technique within the reach of clinicians for the diagnosis and management of newborns and infants with altered lung function.
Thesaurus Terms: biomedical engineering, instrumentation clinically oriented, biomedical systems automated, computer processing of clinical data, children, infant newborn (birth to 4-6 wks), diagnosis, diagnostic tests, design, development and evaluation of diagnostic tests, respiratory disorders diagnosis, respiratory airflow measurements, respiratory disorders, respiratory airflow disorders, computer programming, respiratory function biomedical systems automated, computer assisted diagnosis, children, computer printing-graphics (general), diagnostic tests, non-invasive, respiratory disorders, lung disorders (general), respiratory function, respiration, respiratory function, respiratory airway volume human, clinical
