Holographic volumetric data storage is regarded as offering the best short-term commercial potential for associative and volumetric memories. At present, numerous problems in electronics, optics and materials remain to be solved before this approach can reach a level of reliability and cost effectiveness comparable to conventional, two-dimensional optical and magnetic storage techniques. In particular, we will develop films of bacteriorhodopsin (bR) as the active media in holographic volumetric memories (HVM), and improve the material through chemical stabilization in the films, chromophore substitution and site directed mutagenesia. Our objective is to prepare thin and thick films of bacteriorhodopsin with the following attributes: high cyclicity (>106), high quantum efficiency (>0.6), high sensitivity (1-4 mJ/cm2), adequate diffraction efficiency (>5%), medium-speed writer (200 ms/page or 130 MByte/s), high-speed read (>100 ms/page or >260 MByte/s) and non-destructive read capability. When compared to the current inorganic crystal media as well as the best photopolymers presently available, a 2-20 fold improvement in data storage capacity should be realized. As an optional task we will build and test a prototype paged holographic data storage system.