The goal of this research is to develop electronic design automation (EDA) tools to automate the following three major radiation-hardened-by-design (RHBD) tasks: (1) The capture of RHBD design constraints and design rules for sub-90nm mixed-signal designs in an industry-standard EDA data base, (2) Checking and verifying if a given sub-90nm mixed-signal design satisfies all the RBHD design constraints and rules, generation of RHBD rule violation and coverage analysis reports, and visulization of RHBD rule violations electronically on circuit schematic and layout, and (3) The optimized use of RHBD mitigation rules for the minimal area/performance/power penalty. The proposed EDA tools will be used directly to support DTRA RHBD Phase 3 program for 45nm mixed-signal RHBD design.