Through this effort, we propose to develop SampleFlex, an elastomer-based field-capable sampling technology for collecting and preserving blood samples. Our approach improves upon paper-based blood collection methods which utilize dried filter paper cards for Dried Blood Spots (DBS) by encapsulating the sample within a flexible elastomer package to protect the sample during transport and storage. Retractable microneedle arrays are used to facilitate easy sampling by untrained personnel and prevent contamination during sampling. An enclosed sample storage reservoir provides the same level of sample stability that legacy DBS cards offer while protecting the sample from environmental contaminants.