We will demonstrate that simulation based training with avatars in 3D virtual world scenarios is an effective tool for training medical first responders to CBRNE events by conducting research and development in three areas: Develop Core Curriculum for Medical First Responders: We propose to develop a core curriculum for two CBRNE scenarios: release of sarin gas and explosion of a radioactive "dirty bomb". Elements of the training curriculum include the trainees, learning objectives, training method, performance assessment, and program evaluation. Build and Evaluate Proof of Concept Virtual Environment: Using the core curriculum, we propose to leverage There, Inc.'s distributed simulation and communication platform to develop virtual replicas of the CBRNE events. The virtual environment will operate over the Internet using common PC hardware and will be evaluated by medical first responders for its ability to be a compelling, realistic, and repeatable training environment. Create Technology Roadmap for Scriptable Avatar Health and Injury System: We propose to deliver a technical implementation plan that adds scriptable health and injury behavior that can be programmed by medical experts for use in CBRNE training. We believe this functionality, coupled with ongoing development efforts will lead to a commercialized simulation based training system for medical first responders