Bay Materials, LLC has developed an innovative generally applicable detection method for the rapid and sensitive detection of biological and/or chemical agents: based on the principle of a micro-electromechanical sensor (MEMS) which responds to proprietary molecular signal-amplifying polymers patented by Bay Materials. A PDA based handheld version of the device has been created for functional testing that can conveniently be programmed to accommodate interchangeable, multi-channel sensors for specific analytes of interest such as biomarkers for osmolality, sodium, potassium, proteins and DNA. The proposed system offers an improved level of biochemical molecule detection with accompanying advantages of: small size; comparatively simple detection electronics; rapid response time (minutes); high selectivity; and sufficient sensitivity for obtaining quantifiable measurements in response to PPM level analyte concentrations.