In this program, Nuvera Biosciences, proposes a practical approach to connect diverse molecular events monitored at the genomic and proteomic level. The objective of the proposed project is to develop a much-needed framework to facilitate construction of molecular pathways of pathological or physiological responses from relevant large-scale archived data. Although data repositories are available today for accessing and processing the information generated from genome-wide research, none of these resources offers a complete, integrated view of the data that is crucial for analysis and understanding the relationships between genes and proteins. In the absence of such infrastructure, the research data generated through large-scale gene and protein expression efforts are likely to produce incomplete or inaccurate molecular pathways of response and derive limited benefit in understanding the biological underpinnings of physiologic stress responses. In Phase I, we propose develop a methodology and prototype for integrating information-rich repositories, with gene expression and proteomic-level measurements to facilitate elucidation of physiological-response pathways. The prototype Phase I effort aims at an analytic framework to help visualize upstream and downstream pathway effects and key molecular effectors of a monitored phenomenon irrespective of whether the critical effects are at the genomic or proteomic level
