SBIR-STTR Award

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Nanoparticle System for High Throughput Proteomics
Award last edited on: 6/19/08

Sponsored Program
SBIR
Awarding Agency
NIH : NIGMS
Total Award Amount
$398,040
Award Phase
2
Solicitation Topic Code
-----
Principal Investigator
Cynthia C Bamdad

Company Information

Minerva Biotechnologies Corporation

40 Bear Hill Road
Waltham, MA 02451
   (781) 487-0200
   mail@minervabio.com
   www.minervabio.com
Location: Single
Congr. District: 05
County: Middlesex

Phase I

Contract Number: 1R43GM073485-01
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
2005
Phase I Amount
$199,020
Minerva Biotechnologies is a nanoparticle company that has developed proprietary technology that enables high throughput proteomics. Without the development of new enabling technologies, sequential testing of every possible pair-wise interaction would require about a billion experiments. However, assuming about 40,000 proteins in the proteome and each might interact with five real binding partners, we really only need to identify 160,000 interacting pairs. We reasoned that if we could stably attach a protein to its encoding DMA, and if we could isolate interacting partners from non-interacting proteins, the problem of generating a proteome-wide 3-dimensional interaction map would be soluble. The proposal under review combines the power of yeast 2-hybrid with the accuracy of in vitro testing. This proposal describes a complete nanotechnology system that will enable the mapping of large protein interaction networks in massively parallel format

Phase II

Contract Number: 5R43GM073485-02
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
2006
Phase II Amount
$199,020
Minerva Biotechnologies is a nanoparticle company that has developed proprietary technology that enables high throughput proteomics. Without the development of new enabling technologies, sequential testing of every possible pair-wise interaction would require about a billion experiments. However, assuming about 40,000 proteins in the proteome and each might interact with five real binding partners, we really only need to identify 160,000 interacting pairs. We reasoned that if we could stably attach a protein to its encoding DMA, and if we could isolate interacting partners from non-interacting proteins, the problem of generating a proteome-wide 3-dimensional interaction map would be soluble. The proposal under review combines the power of yeast 2-hybrid with the accuracy of in vitro testing. This proposal describes a complete nanotechnology system that will enable the mapping of large protein interaction networks in massively parallel format.

Public Health Relevance:
This Public Health Relevance is not available.

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