Flint Hills Scientific, LLC specializes in advanced algorithms, and related systems and medical technologies, for real time analysis of complex signals, with special emphasis on brain wave and biologic signals, and mechanisms and device solutions for the automatic prediction, detection, and control of various disease states. FHS has developed a suite algorithms and other related technologies for the analysis of complex signals of arbitrary origin or time-scale, with a primary specialization in analysis of brainwaves. These technologies are also applicable to non-stationary biologic signals in other therapeutic fields such as pain, cardiovascular, and diabetes, to quantify and detect or predict signal changes both accurately and in real-time. Some of the concepts utilized and cultivated by FHS include order statistical analysis, signal normalization, exponential forgetting (and other time and state weighting techniques that allow adaptive learning), modeling and identification, and optimization theory.