SBIR-STTR Award

Genetic vaccination through salivary gland transduction
Award last edited on: 11/25/02

Sponsored Program
SBIR
Awarding Agency
NIH : NIDCR
Total Award Amount
$100,000
Award Phase
1
Solicitation Topic Code
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Principal Investigator
Sean N Tucker

Company Information

Genteric Inc (AKA: Genteric Corporation)

50 Woodside Plaza Suite 102
Redwood City, CA 94061
   (510) 749-6060
   jkelly@genteric.com
   www.genteric.com
Location: Single
Congr. District: 18
County: San Mateo

Phase I

Contract Number: 1R43DE014841-01
Start Date: 00/00/00    Completed: 00/00/00
Phase I year
2002
Phase I Amount
$100,000
A long-term goal in clinical immunology has been the development of vaccines that produce robust mucosal protection. It may be possible to create a new vaccine technology that is superior to existing methods by delivering DNA vaccines to the salivary gland. The proposed research will characterize the immune response to the HIV-1 gp120. Specifically, the proposal addresses the following aims: 1) Demonstrate that salivary gland DNA vaccination results in humoral mucosal immune responses that are superior to other vaccination methods; 2) Evaluate the utility of benign adjuvants to enhance salivary gland vaccination; 3) Determine the extent to which systemic T cell-mediated activity is stimulated 4) Establish protection against mucosal and systemic infection in a challenge model. The critical criteria that will demonstrate the utility of salivary gland DNA vaccination include either a strong mucosal immune response or enhanced T cell mediated response, combined with successful protection in challenge studies. If successful, this demonstration of feasibility will serve as the foundation for additional development towards clinical testing. Understanding more fully the potential of salivary gland vaccination is the first step to evaluating how this technology may compete with existing vaccine technologies, and will likely reveal additional clinical targets.

Thesaurus Terms:
active immunization, cellular immunity, mucosal immunity, salivary gland, technology /technique development, vector vaccine HIV envelope protein gp120, Peyer's patches, cytotoxic T lymphocyte, helper T lymphocyte, immunoglobulin A, immunoglobulin G, immunomodulator, interferon gamma, somatotropin, vaccine development biotechnology, enzyme linked immunosorbent assay, flow cytometry, laboratory rat

Phase II

Contract Number: ----------
Start Date: 00/00/00    Completed: 00/00/00
Phase II year
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Phase II Amount
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