Synthetic oligodeoxynucleotides play a central role in molecular biology research, for example, in DNA sequencing, DNA amplification, and hybridization. A novel "one pot" enzymatic method will replace the cumbersome and exDensive phosphoramidite chemical method. The new method promises increased speed, throughput, reliability, ease of use, and decreased cost for the synthesis of oligonucleotides.Commercial ApplicationsSynthetic oligodeoxynucleotides are established tools for modern medical, clinical, and biological research. This novel enzymatic method for the synthesis of oligos will supplant the existing chemical method due to lower costs and ease of use, ensuring commercial success in a marketplace with an established demand.National Cancer Institute (NCI)
