The long term objective is development of ultrasonic modules for laparoscopic surgery suitable for the minimally invasive removal of cancerous tissue. Modules will operate on the principle of tissue emulsification using ultrasonic oscillations, produced by a vibrating titanium tube, coming in contact with tissues. Operation of such modules will enable the clinician to emulsify and remove tissue with low risk of spillage of cut tissue inside abdomen essential when treating cancer. The technical aim is to develop the ultrasonic horn assembly, to have the dimensions adequate for minimally invasive surgery, and to have the tip vibration characteristics suitable for efficient emulsification of cancerous tissues. The Phase I encompasses the necessary theoretical calculations and modeling required to design and develop prototype ultrasonic device for minimally invasive surgery. The prototype device will be tested in in vitro trials on human cancerous tissues to determine the effectiveness of the device and its optimum parameters. In Phase 11 a modified device will be developed, suitable for in vivo trials on animals and humans, to clinically validate the concept and practice of the device and provide feedback for building of commercial devices.Awardee's statement of the potential commercial applications of the research: Potential commercial applications may result in development, manufacture and sale of systems and devices for ultrasonic, laparoscopic removal of cancer. Possible applications are in OBGYN and general surgery. Some of the procedures which would benefit from such devices are myomectomy, resection of endometriosis and reduction of diaphragmatic metastases.National Cancer Institute (NCI)
