We intend to investigate the potential for liposome encapsulation of Iymphotoxin and its delivery to specific liver cells where lymphotoxin can augment a natural response against tumor. Understanding how the host's natural defense system can be modulated by chemotherapeutic drugs and BRMs in a number of pathologic states is critical in determining their clinical usefulness. Since the liver is a major target of invasion by metastatic tumors, we have selected it as a model organ to accomplish our research aims. We have developed, and will employ in this project, techniques to study the liver's natural antitumor defense system in vitro/ex vitro as well as methods to target immunoenhancing agents to various regions of the murine liver using liposomes of varied size and composition.National Cancer Institute (NCI)
