Company Profile

SignaBlok Inc
Profile last edited on: 12/3/19      CAGE: 5Z7P9      UEI: JM5UN38YM1H7

Business Identifier: Peptide-based technology to block disease-causing signals from T cells
Year Founded
2009
First Award
2012
Latest Award
2020
Program Status
Active
Popularity Index
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Location Information

PO Box 4064
Shrewsbury, MA 01545
   (203) 505-3807
   info@signablok.com
   www.signablok.com
Location: Single
Congr. District: 02
County: Worcester

Public Profile

SignaBlok, Inc. is a biopharmaceutical company developing a new class of therapies – innovative modulatory peptides that can be rationally designed for nearly any cell surface receptor and have broad potential to treat and prevent a wide range of serious diseases with unmet clinical needs. Designated SCHOOL - signaling chain homo-oligomerization - the system is a method of silencing intracellular communication, This novel model of cell signaling - SCHOOL - uncovers the mechanisms of signaling by membrane receptors, a biological process that plays an important role in health and disease; a discovery that potentially opens new avenues for drug development with applications in many serious diseases. SignaBlok is also developing a nanotechnology that enables targeted delivery of SCHOOL peptides and other therapies and/or imaging agents, aiming to improve efficacy, reduce dose, and allow image-guided therapy

Extent of SBIR involvement

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Synopsis: Awardee Business Condition

Employee Range
1-4
Revenue Range
Less than .5M
VC funded?
No
Public/Private
Privately Held
Stock Info
----
IP Holdings
5-9

Awards Distribution by Agency

Most Recent SBIR Projects

Year Phase Agency Total Amount
2020 1 NIH $249,601
Project Title: TREM-1 Inhibitor for the Treatment of Scleroderma
2020 2 NIH $2,224,562
Project Title: First-in-class TREM-1 inhibitors in combination therapy for pancreatic cancer
2020 1 NIH $258,603
Project Title: TREM-1 Therapy for Rheumatoid Arthritis
2020 1 DHA $220,006
Project Title: First-in-class TREM-1 Radioprotector to Prevent the Effects of Acute Radiation Syndrome
2018 1 NIH $224,996
Project Title: Novel Trem-1 Targeting Therapies for Sepsis

Key People / Management

  Alexander B Sigalov -- President and Founder