
Single-molecule protein sequencing by detection and identification of N-terminal amino acidsAward last edited on: 2/10/2024
Sponsored Program
SBIRAwarding Agency
NIH : NHGRITotal Award Amount
$390,584Award Phase
1Solicitation Topic Code
172Principal Investigator
Daniel M EstandianCompany Information
Glyphic Biotechnologies Inc
169 Madison Avenue Suite 2216
New York, NY 10016
New York, NY 10016
(925) 477-7334 |
letschat@glyphic.bio |
www.glyphic.bio |
Location: Single
Congr. District: 15
County: San Mateo
Congr. District: 15
County: San Mateo
Phase I
Contract Number: 1R43HG012960-01Start Date: 8/15/2023 Completed: 7/31/2024
Phase I year
2023Phase I Amount
$390,584Public Health Relevance Statement:
NARRATIVE No current technology is capable of unbiased sequencing of individual proteins in a complex sample. Glyphic Biotechnologies is developing a novel method of single-molecule protein sequencing, analogous to Next-Gen- eration Sequencing of DNA. In conjunction with this technology, Glyphic proposes here to develop reagents to specifically detect N-terminal amino acids for applications in clinical diagnostics and basic research.
Project Terms:
Acceleration; Primary Protein Structure; protein sequence; Amino Acid Sequence; aminoacid; Amino Acids; Antibodies; Clinical Treatment Moab; mAbs; monoclonal Abs; Monoclonal Antibodies; antigen antibody affinity; Antibody Affinity; Biological Assay; Assay; Bioassay; Biologic Assays; Biology; Biotechnology; Biotech; Blood; Blood Reticuloendothelial System; Malignant Neoplasms; Cancers; Malignant Tumor; malignancy; neoplasm/cancer; Charge; Chemistry; Disease; Disorder; Dyes; Coloring Agents; Enzyme-Linked Immunosorbent Assay; ELISA; enzyme linked immunoassay; Face; faces; facial; Future; Growth and Development function; Growth and Development; Immune Sera; Antisera; immune serum; Immunity; Infection; Libraries; Ligation; Closure by Ligation; Llama; Marketing; Methods; Fluorescence Microscopy; Fluorescence Light Microscopy; Mus; Mice; Mice Mammals; Murine; Noise; Parents; parent; Patients; Peptide Mapping; Peptide Fingerprinting; Peptides; Proteins; Oryctolagus cuniculus; Domestic Rabbit; Rabbits; Rabbits Mammals; Reagent; Research; Sensitivity and Specificity; Signal Transduction; Cell Communication and Signaling; Cell Signaling; Intracellular Communication and Signaling; Signal Transduction Systems; Signaling; biological signal transduction; Specificity; Mass Spectrum Analysis; Mass Photometry/Spectrum Analysis; Mass Spectrometry; Mass Spectroscopy; Mass Spectrum; Mass Spectrum Analyses; Technology; Testing; Tumor Antigens; Tumor-Associated Antigen; cancer antigens; tumor-specific antigen; Yeasts; Measures; Titrations; Peptide Domain; Protein Domains; Tertiary Protein Structure; Label; improved; Area; Surface; Solid; Phase; biologic; Biological; Chemicals; Individual; Dysfunction; Physiopathology; pathophysiology; Functional disorder; polyclonal antibody; clinical diagnosis; Knowledge; Hour; Complex; Side; Reaction; System; success; Fluorescence Resonance Energy Transfer; FRET; Förster Resonance Energy Transfer; Surface Plasmon Resonance; molecular mass; immunological diversity; novel; Basic Science; Basic Research; Peptide Sequence Determination; Amino Acid Sequence Determinations; Protein Sequence Determinations; Protein Sequencing; Protein Sequencing Molecular Biology; Proteome; Sampling; cross reactivity; Proteomics; single molecule; Genomics; Molecular Interaction; Binding; protein expression; protein complex; Complex Mixtures; protein structure; protein structures; proteins structure; Affinity; Detection; Diagnostics Research; Protein Analysis; Resolution; resolutions; Process; protein function; Development; developmental; Image; imaging; digital; next generation; new approaches; novel approaches; novel strategy; novel strategies; nano pore; nanopore; cost effective; pathogen; NH2-terminal; N-terminal; innovate; innovative; innovation; antibody engineering; commercialization; tumor; bio-markers; biologic marker; biomarker; Biological Markers; disease diagnosis; NGS Method; NGS system; next gen sequencing; nextgen sequencing; next generation sequencing; sequencing platform; medical diagnostic; clinical diagnostics; Immunize; DNA seq; DNAseq; DNA sequencing; Visualization; manufacture
Phase II
Contract Number: ----------Start Date: 00/00/00 Completed: 00/00/00