SBIR-STTR Award

Enhanced Medication Management to Control ADRD Risk Factors Among African Americans and Latinos
Award last edited on: 2/8/2024

Sponsored Program
SBIR
Awarding Agency
NIH : NIA
Total Award Amount
$299,553
Award Phase
1
Solicitation Topic Code
866
Principal Investigator
Alvin Ramsey

Company Information

Pilltrax Systems LLC

1992 Commonwealth Avenue Apt 4
Brighton, MA 02135
   (571) 236-6808
   N/A
   www.pilltrax.com
Location: Single
Congr. District: 07
County: Suffolk

Phase I

Contract Number: 2023
Start Date: ----    Completed: 9/18/2023
Phase I year
2023
Phase I Amount
$299,553
/Alzheimer's disease and related dementias (ADRD) disproportionately affects minorities - African Americans are 2x more likely and Hispanics/Latinos are 1.5x more likely than white Americans to have ADRD. Recently, the Alzheimer's Impact Movement (AIM) and the Alzheimer's Association supported the recommendation of "better management of risk factors - particularly high blood pressure and diabetes - to reduce the risk of ADRD among African Americans and Hispanics/Latinos." Medications can be very effective in managing both hypertension and diabetes, but unfortunately adherence to these medications is commonly low, particularly among African Americans and Hispanics/Latinos. Marginal adherence (60%-80%) with anti-hypertensive medication is inadequate because these patients still had significantly elevated risks (3x greater compared to fully adherent, 2.5x greater compared to highly adherent) of developing ADRD. Hence, an effective pro-active solution for optimizing medication adherence can positively impact this patient population. The proposed solution will be a medication management service designed for providers. The full solution would comprise of: (A) a commercially available electronic pill dispenser that sends SMS notifications of pills taken/missed, (B)future adherence assessment based on historical data, and (C) a provider portal which presents adherence-related information. To address the disparity in ADRD among African Americans and Latinos, the initial implementation will specifically focus on providers who deliver care to older adults in these communities.

Public Health Relevance Statement:
Project Narrative The proposed solution will be a medication management service designed for providers. The solution will support the care of risk factors for Alzheimer's disease and related dementia with older adults in the African American and Latino patient population.

Project Terms:
Adoption; Affect; advanced age; elders; geriatric; late life; later life; older adult; older person; senior citizen; Elderly; Algorithms; AD dementia; Alzheimer Type Dementia; Alzheimer disease dementia; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimers Dementia; Primary Senile Degenerative Dementia; primary degenerative dementia; senile dementia of the Alzheimer type; Alzheimer's Disease; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Hypotensive Agent; Hypotensive Drugs; anti-hypertension; Communities; Diabetes Mellitus; diabetes; Pharmaceutical Preparations; Drugs; Medication; Pharmaceutic Preparations; drug/agent; Electronics; electronic; electronic device; Expenditure; Feedback; Future; Goals; Recording of previous events; History; histories; Hypertension; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; high blood pressure; hyperpiesia; hyperpiesis; hypertensive disease; hypertensive disorder; Morbidity - disease rate; Morbidity; Movement; body movement; Patients; Recommendation; Risk; Risk Factors; Risk Management; Surveys; Survey Instrument; Testing; Time; United States Agency for Healthcare Research and Quality; AHCPR; AHRQ; Agency for Health Care Policy and Research; Agency for Healthcare Research and Quality; United States Agency for Health Care Policy and Research; Afro American; Afroamerican; African American; Latino; Analgesic Management; Pharmacologic Management; medication therapy management; Medication Management; Caring; improved; Phase; Medical; Logistic Regressions; Training; white American; caucasian American; Early Intervention; Machine Learning; machine based learning; Notification; System; interest; Visit; Services; Early Diagnosis; early detection; success; Participant; empowerment; Categories; Antidiabetic Drugs; Anti-diabetic Agents; Antidiabetic Agents; anti-diabetic; anti-diabetic drugs; antidiabetic; pill; reduce risk; reduce risks; reduce that risk; reduce the risk; reduce these risks; reduces risk; reduces the risk; reducing risk; reducing the risk; risk-reducing; Risk Reduction; Provider; Address; Adherence; Age Years; Data; trend; medication compliance; drug adherence; drug compliance; medication adherence; computer based prediction; prediction model; predictive modeling; designing; design; Minority; innovate; innovative; innovation; Alzheimer risk factor; alzheimer risk; Alzheimer's disease risk; patient population; predictive algorithm; predictor algorithm; prediction algorithm; predictive tools; cloud server; cloud platform; random forest; AD related dementia; ADRD; Alzheimer's and related dementias; Alzheimer's disease and related dementia; Alzheimer's disease and related disorders; Alzheimer's disease or a related dementia; Alzheimer's disease or a related disorder; Alzheimer's disease or related dementia; Alzheimer's disease related dementia; risk factor for dementia; risk for dementia; dementia risk; algorithm training; Latino Population; Latino group; Latino individual; Latino people; Latinos; provider portal; Hispanic Populations; Hispanic group; Hispanic individual; Hispanic people; Hispanics; African American population; African American group; African American individual; African American people; African Americans; Disparity; Disparities

Phase II

Contract Number: 1R43AG081035-01
Start Date: 8/31/2024    Completed: 00/00/00
Phase II year
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Phase II Amount
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