Single-strand DNA repair (ssDR) is critical for preventing genomic catastrophe. AnaNeo Therapeutics wasfounded by experts in DNA repair mechanisms. Extending our team's previous fundamental ssDR studies weanalyzed >61,000 tumors for somatic mutations, generated isogenic mutant/wild-type cell line pairs, screenedtwo isogenic cell line pairs with small molecule libraries, performed computational and experimental syntheticlethality (SL) screens and used state-of-the-art Schrodinger Maestro drug docking software to nominate smallmolecule ssDR SL hits. Here in this Phase I STTR project we propose to validate candidate targets and smallmolecule inhibitors. Overall, this study will nominate innovative ssDR SL precision therapy targets and smallmolecule hits for lead optimization in future Phase II SBIR studies.
Public Health Relevance Statement: Single-strand DNA repair is critical for preventing genomic catastrophe. We have screened drug and gene
mutation libraries to identify novel cancer therapy compounds for tumors that carry DNA repair mutations. This
study will validate innovative precision cancer therapy targets to help patients whose tumors carry DNA repair
mutations.
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